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Evolution and development of the tetrapod auditory system: an organ of Corti‐centric perspective
Journal article   Peer reviewed

Evolution and development of the tetrapod auditory system: an organ of Corti‐centric perspective

Bernd Fritzsch, Ning Pan, Israt Jahan, Jeremy S Duncan, Benjamin J Kopecky, Karen L Elliott, Jennifer Kersigo and Tian Yang
Evolution & development, Vol.15(1), pp.63-79
01/2013
DOI: 10.1111/ede.12015
PMCID: PMC3918746
PMID: 23331918
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3918746View
Open Access

Abstract

SUMMARY The tetrapod auditory system transmits sound through the outer and middle ear to the organ of Corti or other sound pressure receivers of the inner ear where specialized hair cells translate vibrations of the basilar membrane into electrical potential changes that are conducted by the spiral ganglion neurons to the auditory nuclei. In other systems, notably the vertebrate limb, a detailed connection between the evolutionary variations in adaptive morphology and the underlying alterations in the genetic basis of development has been partially elucidated. In this review, we attempt to correlate evolutionary and partially characterized molecular data into a cohesive perspective of the evolution of the mammalian organ of Corti out of the tetrapod basilar papilla. We propose a stepwise, molecularly partially characterized transformation of the ancestral, vestibular developmental program of the vertebrate ear. This review provides a framework to decipher both discrete steps in development and the evolution of unique functional adaptations of the auditory system. The combined analysis of evolution and development establishes a powerful cross‐correlation where conclusions derived from either approach become more meaningful in a larger context which is not possible through exclusively evolution or development centered perspectives. Selection may explain the survival of the fittest auditory system, but only developmental genetics can explain the arrival of the fittest auditory system. [Modified after (Wagner 2011)]

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