Journal article
Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis
Diabetes care, Vol.37(6), pp.1741-1744
06/2014
DOI: 10.2337/dc13-2612
PMCID: PMC4030093
PMID: 24696460
Abstract
To examine the evolution of the dysregulated glucagon responses to mixed-meal tolerance tests (MMTTs) in youth with recent-onset type 1 diabetes (T1D).
MMTTs were performed in 25 youth (9-18 years of age) with 1.5-12 months disease duration (year 1); 22 subjects were restudied 1 year later (year 2). Twenty nondiabetic (ND) control children were also studied.
In T1D children, MMTT-stimulated increases in glucagon were significantly greater than that in ND children (median increments: year 1, 21 pg/mL [16-30]; year 2, 25 pg/mL [16-30]; ND, 9 pg/mL [5-16]; P = 0.001 and P < 0.001, respectively).
In comparison with ND control children, exaggerated plasma glucagon responses to mixed-meal feedings are observed in youth with T1D within the first 2 years of diagnosis. Further studies to determine whether suppression of these abnormal responses may help to improve glycemic control are warranted.
Details
- Title: Subtitle
- Evolution of abnormal plasma glucagon responses to mixed-meal feedings in youth with type 1 diabetes during the first 2 years after diagnosis
- Creators
- Jennifer Sherr - Section of Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CTEva Tsalikian - Endocrinology and Diabetes, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IALarry Fox - Pediatric Endocrinology, Nemours Children's Clinic, Jacksonville, FLBruce Buckingham - Division of Pediatric Endocrinology and Diabetes, Stanford University, Stanford, CAStuart Weinzimer - Section of Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CTWilliam V Tamborlane - Section of Endocrinology, Department of Pediatrics, Yale University School of Medicine, New Haven, CTNeil H White - Department of Pediatrics, Washington University in St. Louis, St. Louis, MOAna Maria Arbelaez - Department of Pediatrics, Washington University in St. Louis, St. Louis, MOCraig Kollman - Jaeb Center for Health Research, Tampa, FLKatrina J Ruedy - Jaeb Center for Health Research, Tampa, FL direcnet@jaeb.orgPeiyao Cheng - Jaeb Center for Health Research, Tampa, FLRoy W Beck - Jaeb Center for Health Research, Tampa, FLDiabetes Research in Children Network
- Resource Type
- Journal article
- Publication Details
- Diabetes care, Vol.37(6), pp.1741-1744
- DOI
- 10.2337/dc13-2612
- PMID
- 24696460
- PMCID
- PMC4030093
- NLM abbreviation
- Diabetes Care
- ISSN
- 0149-5992
- eISSN
- 1935-5548
- Grant note
- UL1 TR000142 / NCATS NIH HHS K12-DK-094714-01 / NIDDK NIH HHS U10 HD041906 / NICHD NIH HHS KL2 RR024994 / NCRR NIH HHS UL1 TR000448 / NCATS NIH HHS HD-41890-10 / NICHD NIH HHS U10 HD041915 / NICHD NIH HHS HD-41918 / NICHD NIH HHS UL1 RR024139 / NCRR NIH HHS HD-41915 / NICHD NIH HHS UL1-RR-024139 / NCRR NIH HHS P30 DK045735 / NIDDK NIH HHS UL1-RR-024150 / NCRR NIH HHS U10 HD041890 / NICHD NIH HHS UL1 RR024150 / NCRR NIH HHS HD-41906-10 / NICHD NIH HHS HD-41908-10 / NICHD NIH HHS UL1 TR001085 / NCATS NIH HHS HD-56526 / NICHD NIH HHS U10 HD041918 / NICHD NIH HHS K12 DK094714 / NIDDK NIH HHS UL1 RR025744 / NCRR NIH HHS U10 HD041908 / NICHD NIH HHS UL1 RR024992 / NCRR NIH HHS UL1 RR024979 / NCRR NIH HHS U10 HD056526 / NICHD NIH HHS UL1-RR-024992 / NCRR NIH HHS UL1-RR-024979 / NCRR NIH HHS U01 HD041890 / NICHD NIH HHS UL1-RR-025744 / NCRR NIH HHS
- Language
- English
- Date published
- 06/2014
- Academic Unit
- Stead Family Department of Pediatrics; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984093227102771
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