Journal article
Evolution of cross-linked non-viral gene delivery systems
Current opinion in molecular therapeutics, Vol.3(2), pp.142-146
04/2001
PMID: 11338926
Abstract
Developing a non-viral gene delivery system that functions in vivo raises the challenge of finding solutions to efficiently deliver DNA to the cell surface that are also compatible with the efficient release of DNA into the cytosol. The stability, particle size and charge of DNA polyplexes and lipoplexes may be optimized to mediate efficient in vitro transfection only to find that different properties are necessary for successful in vivo transfection. Despite their versatility and improved safety, non-viral gene vectors still lack appreciable in vivo transfection efficiency compared to viral vectors. An emerging theme in recent studies is the use of cross-linking to achieve balance between the stability of polyplexes and lipoplexes in the blood and the controlled release of DNA in the cytosol. This review evaluates the evolution of cross-linking strategies aimed at transiently stabilizing non-viral gene delivery systems.
Details
- Title: Subtitle
- Evolution of cross-linked non-viral gene delivery systems
- Creators
- K Y Kwok - Departments of Pharmaceutics and Medicinal Chemistry, College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, MI 48109-1065, USA. krice@umich.eduY YangK G Rice
- Resource Type
- Journal article
- Publication Details
- Current opinion in molecular therapeutics, Vol.3(2), pp.142-146
- PMID
- 11338926
- NLM abbreviation
- Curr Opin Mol Ther
- ISSN
- 1464-8431
- Publisher
- England
- Language
- English
- Date published
- 04/2001
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Medicinal and Natural Products Chemistry
- Record Identifier
- 9984065319302771
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