Journal article
Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells
Frontiers in cellular neuroscience, Vol.12, pp.252-252
08/08/2018
DOI: 10.3389/fncel.2018.00252
PMCID: PMC6092489
PMID: 30135646
Abstract
We review the evolution and development of organ of Corti hair cells with a focus on their molecular differences from vestibular hair cells. Such information is needed to therapeutically guide organ of Corti hair cell development in flat epithelia and generate the correct arrangement of different hair cell types, orientation of stereocilia, and the delayed loss of the kinocilium that are all essential for hearing, while avoiding driving hair cells toward a vestibular fate. Highlighting the differences from vestibular organs and defining what is known about the regulation of these differences will help focus future research directions toward successful restoration of an organ of Corti following long-term hair cell loss.
Details
- Title: Subtitle
- Evolutionary and Developmental Biology Provide Insights Into the Regeneration of Organ of Corti Hair Cells
- Creators
- Karen L Elliott - Department of Biology, University of IowaBernd Fritzsch - Department of Biology, University of IowaJeremy S Duncan - Department of Biological Sciences, Western Michigan University
- Resource Type
- Journal article
- Publication Details
- Frontiers in cellular neuroscience, Vol.12, pp.252-252
- DOI
- 10.3389/fncel.2018.00252
- PMID
- 30135646
- PMCID
- PMC6092489
- NLM abbreviation
- Front Cell Neurosci
- ISSN
- 1662-5102
- eISSN
- 1662-5102
- Publisher
- Frontiers Media S.A
- Grant note
- RO1 DC005590 to BF; R03 DC015333 to KE / National Institutes of Health
- Language
- English
- Date published
- 08/08/2018
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070673302771
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