Journal article
Ex Vivo Liver Resection and Autotransplantation Should It be Used More Frequently?
Annals of surgery, Vol.276(5), pp.854-859
11/01/2022
DOI: 10.1097/SLA.0000000000005640
PMID: 35920562
Abstract
Objective: We herein advocate for more extensive utilization of ex vivo resection techniques for otherwise unresectable liver tumors by presenting the largest collective American experience. Background: Advanced in situ resection and vascular reconstruction techniques have made R0 resection possible for otherwise unresectable liver tumors. Ex vivo liver resection may further expand the limits of resectability but remains underutilized due to concerns about technical complexity and vascular thrombosis. However, we believe that the skillset required for ex vivo liver resection is more widespread and the complications less severe than widely assumed, making ex vivo resection a more attractive option in selected case. Methods: We retrospectively analyzed 35 cases performed by surgical teams experienced with ex vivo liver resections (at least 4 cases) between 1997 and 2021. Results: We categorized malignancies as highly aggressive (n=18), moderately aggressive (n=14), and low grade (n=3). All patients underwent total hepatectomy, vascular reconstruction and resection in hypothermia on the backtable, and partial liver autotransplantation. Overall survival was 67%/39%/28%, at 1/3/5 years, respectively, with a median survival of 710 days (range: 22-4824). Patient survival for highly aggressive, moderately aggressive, and low-grade tumors was 61%/33%/23%, 67%/40%/22%, and 100%/100%/100% at 1/3/5 years, respectively, with median survival 577 days (range: 22-3873), 444 days (range: 22-4824), and 1825 days (range: 868-3549). Conclusions: Ex vivo resection utilizes techniques commonly practiced in partial liver transplantation, and we demonstrate relatively favorable outcomes in our large collective experience. Therefore, we propose that more liberal use of this technique may benefit selected patients in centers experienced with partial liver transplantation.
Details
- Title: Subtitle
- Ex Vivo Liver Resection and Autotransplantation Should It be Used More Frequently?
- Creators
- Joshua Weiner - Columbia UniversityAlan Hemming - University of IowaDavid Levi - Carolinas Medical CenterThiago Beduschi - University of FloridaRei Matsumoto - Columbia UniversityAbhishek Mathur - Columbia UniversityPeter Liou - Columbia UniversityAdam Griesemer - Columbia UniversityBenjamin Samstein - Weill Cornell MedicineDaniel Cherqui - Hôpital Paul-BrousseJean Emond - Columbia UniversityTomoaki Kato - Columbia University
- Resource Type
- Journal article
- Publication Details
- Annals of surgery, Vol.276(5), pp.854-859
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1097/SLA.0000000000005640
- PMID
- 35920562
- ISSN
- 0003-4932
- eISSN
- 1528-1140
- Number of pages
- 6
- Language
- English
- Date published
- 11/01/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984321866602771
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