Journal article
Exaggerated Blood Pressure Variability Superimposed on Hypertension Aggravates Cardiac Remodeling in Rats via Angiotensin II System-Mediated Chronic Inflammation
Hypertension (Dallas, Tex. 1979), Vol.54(4), pp.832-U288
10/2009
DOI: 10.1161/HYPERTENSIONAHA.109.135905
PMID: 19704105
Abstract
Hypertensive patients with large blood pressure variability (BPV) have aggravated end-organ damage. However, the pathogenesis remains unknown. We investigated whether exaggerated BPV aggravates hypertensive cardiac remodeling and function by activating inflammation and angiotensin II -mediated mechanisms. A model of exaggerated BPV superimposed on chronic hypertension was created by performing bilateral sinoaortic denervation (SAD) in spontaneously hypertensive rats (SHRs). SAD increased BPV to a similar extent in Wistar Kyoto rats and SHRs without significant changes in mean blood pressure. SAD aggravated left ventricular and myocyte hypertrophy and myocardial fibrosis to a greater extent and impaired left ventricular systolic function in SHRs. SAD induced monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen mRNA upregulations and macrophage infiltration of the heart in SHRs. The effects of SAD on cardiac remodeling and inflammation were much smaller in Wistar Kyoto rats compared with SHRs. Circulating levels of norepinephrine, the active form of renin, and inflammatory cytokines were not affected by SAD in Wistar Kyoto rats and SHRs. A subdepressor dose of candesartan abolished the SAD-induced left ventricular/myocyte hypertrophy, myocardial fibrosis, macrophage infiltration, and inductions of monocyte chemoattractant protein-1, transforming growth factor-beta, and angiotensinogen and subsequently prevented systolic dysfunction in SHRs with SAD. These findings suggest that exaggerated BPV induces chronic myocardial inflammation and thereby aggravates cardiac remodeling and systolic function in hypertensive hearts. The cardiac angiotensin II system may play a role in the pathogenesis of cardiac remodeling and dysfunction induced by a combination of hypertension and exaggerated BPV. (Hypertension. 2009; 54: 832-838.)
Details
- Title: Subtitle
- Exaggerated Blood Pressure Variability Superimposed on Hypertension Aggravates Cardiac Remodeling in Rats via Angiotensin II System-Mediated Chronic Inflammation
- Creators
- Hiroshi Kudo - Kurume UniversityHisashi Kai - Kurume UniversityHidemi Kajimoto - Kurume UniversityMitsuhisa Koga - Kurume UniversityNarimasa Takayama - Kurume UniversityTakahiro Mori - Kurume UniversityAyami Ikeda - Kurume UniversitySuguru Yasuoka - Kurume UniversityTakahiro Anegawa - Kurume UniversityHiroharu Mifune - Kurume UniversitySeiya Kato - Kyushu UniversityYoshitaka Hirooka - Kyushu UniversityTsutomu Imaizumi - Kurume University
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.54(4), pp.832-U288
- DOI
- 10.1161/HYPERTENSIONAHA.109.135905
- PMID
- 19704105
- NLM abbreviation
- Hypertension
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Publisher
- Lippincott Williams & Wilkins
- Number of pages
- 19
- Grant note
- Kakihara Science Foundation Takeda Science Foundation; Takeda Science Foundation (TSF) Science Frontier Research Promotion Centers (Cardiovascular Research Institute) Kimura Memorial Heart Foundation Ishibashi Memorial Foundation Ministry of Education, Science, Sports and Culture, Japan; Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)
- Language
- English
- Date published
- 10/2009
- Academic Unit
- Cardiology; Stead Family Department of Pediatrics
- Record Identifier
- 9984961113302771
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