Journal article
Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood
Psychological medicine, Vol.54(2), pp.267-277
01/2024
DOI: 10.1017/S0033291723001174
PMCID: PMC11010461
PMID: 37203444
Abstract
Researchers have identified genetic and neural risk factors for externalizing behaviors. However, it has not yet been determined if genetic liability is conferred in part through associations with more proximal neurophysiological risk markers.
Participants from the Collaborative Study on the Genetics of Alcoholism, a large, family-based study of alcohol use disorders were genotyped and polygenic scores for externalizing (EXT PGS) were calculated. Associations with target P3 amplitude from a visual oddball task (P3) and broad endorsement of externalizing behaviors (indexed via self-report of alcohol and cannabis use, and antisocial behavior) were assessed in participants of European (EA;
= 2851) and African ancestry (AA;
= 1402). Analyses were also stratified by age (adolescents, age 12-17 and young adults, age 18-32).
The EXT PGS was significantly associated with higher levels of externalizing behaviors among EA adolescents and young adults as well as AA young adults. P3 was inversely associated with externalizing behaviors among EA young adults. EXT PGS was not significantly associated with P3 amplitude and therefore, there was no evidence that P3 amplitude indirectly accounted for the association between EXT PGS and externalizing behaviors.
Both the EXT PGS and P3 amplitude were significantly associated with externalizing behaviors among EA young adults. However, these associations with externalizing behaviors appear to be independent of each other, suggesting that they may index different facets of externalizing.
Details
- Title: Subtitle
- Examining associations between genetic and neural risk for externalizing behaviors in adolescence and early adulthood
- Creators
- Sarah J Brislin - Rutgers, The State University of New JerseyJessica E Salvatore - Rutgers, The State University of New JerseyJacquelyn M Meyers - Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USAChella Kamarajan - Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USAMartin H Plawecki - Indiana University BloomingtonHoward J Edenberg - Indiana University BloomingtonSamuel Kuperman - University of IowaJay Tischfield - Rutgers, The State University of New JerseyVictor Hesselbrock - University of ConnecticutAndrey P Anokhin - Washington University in St. LouisDavid B Chorlian - Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USAMarc A Schuckit - University of California San DiegoJohn I Nurnberger Jr - Indiana University BloomingtonLance Bauer - University of ConnecticutGayathri Pandey - Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USAAshwini K Pandey - Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USAJohn R Kramer - University of IowaGrace Chan - Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USABernice Porjesz - Department of Psychiatry and Behavioral Sciences, State University of New York Downstate Medical Center, New York, NY, USADanielle M Dick - Rutgers, The State University of New JerseyCOGA Collaborators
- Resource Type
- Journal article
- Publication Details
- Psychological medicine, Vol.54(2), pp.267-277
- DOI
- 10.1017/S0033291723001174
- PMID
- 37203444
- PMCID
- PMC11010461
- NLM abbreviation
- Psychol Med
- eISSN
- 1469-8978
- Grant note
- R01DA050721 / NIDA NIH HHS
- Language
- English
- Electronic publication date
- 05/19/2023
- Date published
- 01/2024
- Academic Unit
- Psychiatry
- Record Identifier
- 9984410786202771
Metrics
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