Journal article
Examining resting-state functional connectivity in key hubs of the default mode network in chronic low back pain
Scandinavian journal of pain, Vol.21(4), pp.839-846
10/26/2021
DOI: 10.1515/sjpain-2020-0184
PMID: 34378878
Abstract
Objectives: Changes in brain connectivity have been observed within the default mode network (DMN) in chronic low back pain (CLBP), however the extent of these disruptions and how they may be related to CLBP requires further examination. While studies using seed-based analysis have found disrupted functional connectivity in the medial prefrontal cortex (mPFC), a major hub of the DMN, limited studies have investigated other equally important hubs, such as the posterior cingulate cortex (PCC) in CLBP.
Methods: This preliminary study comprised 12 individuals with CLBP and 12 healthy controls who completed a resting-state functional magnetic resonance imaging (fMRI) scan. The mPFC and PCC were used as seeds to assess functional connectivity.
Results: Both groups displayed similar patterns of DMN connectivity, however group comparisons showed that CLBP group had reduced connectivity between the PCC and angular gyrus compared to healthy controls. An exploratory analysis examined whether the alterations observed in mPFC and PCC connectivity were related to pain catastrophizing in CLBP, but no significant associations were observed.
Conclusions: These results may suggest alterations in the PCC are apparent in CLBP, however, the impact and functional role of these disruptions require further investigation.
Details
- Title: Subtitle
- Examining resting-state functional connectivity in key hubs of the default mode network in chronic low back pain
- Creators
- Sin Ki Ng - Monash UniversityDonna M. Urquhart - Monash UniversityPaul B. Fitzgerald - Monash UniversityFlavia M. Cicuttini - Monash UniversityMelissa Kirkovski - Deakin UniversityJerome J. Maller - Monash Alfred Psychiatry Research centrePeter G. Enticott - Deakin UniversitySusan L. Rossell - Swinburne University of TechnologyBernadette M. Fitzgibbon - Epworth Hospital
- Resource Type
- Journal article
- Publication Details
- Scandinavian journal of pain, Vol.21(4), pp.839-846
- DOI
- 10.1515/sjpain-2020-0184
- PMID
- 34378878
- NLM abbreviation
- Scand J Pain
- ISSN
- 1877-8860
- eISSN
- 1877-8879
- Publisher
- Walter De Gruyter
- Number of pages
- 8
- Grant note
- 1078567; 1154651 / National Health and Medical Research Council (NHMRC); National Health & Medical Research Council (NHMRC) of Australia 1142809 / National Health and Medical Research Council (NHMRC) Career Development Fellowship; National Health & Medical Research Council (NHMRC) of Australia 1154651; 1070073 / National Health and Medical Research Council of Australia; National Health & Medical Research Council (NHMRC) of Australia 1070073 / NHMRC; National Health & Medical Research Council (NHMRC) of Australia FT160100077 / Australian Research Council (ARC); Australian Research Council
- Language
- English
- Date published
- 10/26/2021
- Academic Unit
- Radiology
- Record Identifier
- 9984848425502771
Metrics
1 Record Views