Journal article
Examining the Cardiac NK-2 Genes in Early Heart Development
Pediatric cardiology, Vol.31(3), pp.335-341
04/2010
DOI: 10.1007/s00246-009-9605-0
PMCID: PMC2981039
PMID: 19967350
Abstract
The cardiac NK-2 transcription factors are the vertebrate relatives of the
Drosophila tinman
gene. Without the
Drosophila tinman
gene, fruit flies fail to form their heart (“dorsal vessel”), and mutations or altered expression of cardiac NK-2 genes may lead to abnormal heart formation in vertebrates. Although the cardiac NK-2 gene
NKX2–5
is recognized as an important factor in cases of human congenital heart disease and heart development in vertebrates, the roles of the other cardiac NK-2 genes are less clear. This report reviews what is known about the cardiac NK-2 genes in cardiac development, comparing studies in several different model systems.
Details
- Title: Subtitle
- Examining the Cardiac NK-2 Genes in Early Heart Development
- Creators
- Heather Bartlett - Department of Pediatrics, University of Iowa, Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USAGert Jan C Veenstra - Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The NetherlandsDaniel L Weeks - Department of Biochemistry, University of Iowa, Bowen Science Building, 51 Newton Road, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Pediatric cardiology, Vol.31(3), pp.335-341
- DOI
- 10.1007/s00246-009-9605-0
- PMID
- 19967350
- PMCID
- PMC2981039
- NLM abbreviation
- Pediatr Cardiol
- ISSN
- 0172-0643
- eISSN
- 1432-1971
- Language
- English
- Date published
- 04/2010
- Academic Unit
- Stead Family Department of Pediatrics; Biochemistry and Molecular Biology
- Record Identifier
- 9984024415702771
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