Journal article
Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A
Learning & memory (Cold Spring Harbor, N.Y.), Vol.16(6), pp.367-370
06/2009
DOI: 10.1101/lm.1231009
PMCID: PMC2704102
PMID: 19470652
Abstract
It is well established that cAMP signaling within neurons plays a major role in the formation of long-term memories—signaling thought to proceed through protein kinase A (PKA). However, here we show that exchange protein activated by cAMP (Epac) is able to enhance the formation of long-term memory in the hippocampus and appears to do so independent of PKA, thus demonstrating the importance of Epac-mediated signaling in memory consolidation.
Details
- Title: Subtitle
- Exchange protein activated by cAMP enhances long-term memory formation independent of protein kinase A
- Creators
- Nan Ma - University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USATed Abel - University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USAPepe J Hernandez - University of Pennsylvania, Department of Biology, Philadelphia, Pennsylvania 19104, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.16(6), pp.367-370
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.1231009
- PMID
- 19470652
- PMCID
- PMC2704102
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Language
- English
- Date published
- 06/2009
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065822702771
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