Executive dysfunction in Parkinson’s disease and timing deficits

Krystal L Parker; Dronacharya Lamichhane; Marcelo S Caetano; Nandakumar S Narayanan

doi:10.3389/fnint.2013.00075

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Executive dysfunction in Parkinson’s disease and timing deficits

Journal article

Open access

Peer reviewed

Executive dysfunction in Parkinson’s disease and timing deficits

Krystal L Parker, Dronacharya Lamichhane, Marcelo S Caetano and Nandakumar S Narayanan

Frontiers in integrative neuroscience, Vol.7, pp.75-75

10/31/2013

DOI: 10.3389/fnint.2013.00075

PMCID: PMC3813949

PMID: 24198770

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Abstract

Patients with Parkinson’s disease (PD) have deficits in perceptual timing, or the perception and estimation of time. PD patients can also have cognitive symptoms, including deficits in executive functions such as working memory, planning, and visuospatial attention. Here, we discuss how PD-related cognitive symptoms contribute to timing deficits. Timing is influenced by signaling of the neurotransmitter dopamine in the striatum. Timing also involves the frontal cortex, which is dysfunctional in PD. Frontal cortex impairments in PD may influence memory subsystems as well as decision processes during timing tasks. These data suggest that timing may be a type of executive function. As such, timing can be used to study the neural circuitry of cognitive symptoms of PD as they can be studied in animal models. Performance of timing tasks also maybe a useful clinical biomarker of frontal as well as striatal dysfunction in PD.

Neuroscience

cognitive impairment

temporal processing

interval timing

Parkinson’s disease

executive function

Details

Title: Subtitle: Executive dysfunction in Parkinson’s disease and timing deficits
Creators: Krystal L Parker - Department of Neurology, University of Iowa Hospitals and Clinics
Dronacharya Lamichhane - Department of Neurology, University of Iowa Hospitals and Clinics
Marcelo S Caetano - Center for Mathematics, Computation and Cognition, Universidade Federal do ABC
Nandakumar S Narayanan - Aging Mind and Brain Initiative, University of Iowa Hospitals and Clinics
Resource Type: Journal article
Publication Details: Frontiers in integrative neuroscience, Vol.7, pp.75-75
DOI: 10.3389/fnint.2013.00075
PMID: 24198770
PMCID: PMC3813949
NLM abbreviation: Front Integr Neurosci
ISSN: 1662-5145
eISSN: 1662-5145
Publisher: Frontiers Media S.A
Language: English
Date published: 10/31/2013
Academic Unit: Neurology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984003453002771

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