Journal article
Executive function and genetic predisposition to schizophrenia - The Maudsley Family Study
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.147B(3), pp.285-293
04/05/2008
DOI: 10.1002/ajmg.b.30594
PMID: 17853391
Abstract
Executive cognitive impairment has been found in families affected by schizophrenia and is a putative endophenotype. We wished to explore its genetic basis further by studying the association between impairment and genetic loading for schizophrenia. We studied 30 schizophrenia patients with a family history of schizophrenia, 53 of their nonpsychotic first-degree relatives (familial), 32 patients with schizophrenia but no known family history of psychosis, 52 of their first-degree relatives (nonfamilial), and 47 normal controls. They were tested using the National Adult Reading Test (NART), Trails A and B, Verbal fluency tasks, and a computerized version of the Wisconsin Card Sorting Test (WCST). Familial, but not nonfamilial, relatives were impaired on NART, letter fluency, Trails B, and WCST total errors. They were inferior to nonfamilial relatives on letter fluency and Trails A. Both sets of relatives were impaired on Trails B controlling for Trails A, and on WCST categories achieved. There were no significant differences between schizophrenia patients with and without a family history. Our results suggest that executive deficits qualitatively similar to those seen in those with schizophrenia reflect familial susceptibility, even taking early IQ and education into consideration, consistent with a genetic mechanism. (C) 2007 Wiley-Liss, Inc.
Details
- Title: Subtitle
- Executive function and genetic predisposition to schizophrenia - The Maudsley Family Study
- Creators
- P. Birkett - University of SheffieldT. Sigmundsson - National University Hospital of IcelandT. Sharma - CognITT. Toulopoulou - King's College LondonT. D. Griffiths - Newcastle UniversityA. Reveley - Maudsley HospitalR. Murray - King's College London
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.147B(3), pp.285-293
- Publisher
- Wiley
- DOI
- 10.1002/ajmg.b.30594
- PMID
- 17853391
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Number of pages
- 9
- Language
- English
- Date published
- 04/05/2008
- Academic Unit
- Psychological and Brain Sciences
- Record Identifier
- 9984627346602771
Metrics
9 Record Views