Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

David B Sacks; Mark Arnold; George L Bakris; David E Bruns; Andrea Rita Horvath; M Sue Kirkman; Ake Lernmark; Boyd E Metzger; David M Nathan

doi:10.1373/clinchem.2011.163634

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Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

Journal article

Open access

Peer reviewed

Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus

David B Sacks, Mark Arnold, George L Bakris, David E Bruns, Andrea Rita Horvath, M Sue Kirkman, Ake Lernmark, Boyd E Metzger and David M Nathan

Clinical chemistry (Baltimore, Md.), Vol.57(6), pp.793-1423

06/2011

DOI: 10.1373/clinchem.2011.163634

PMID: 21617153

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Abstract

Multiple laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled evidence-based recommendations for the use of laboratory analysis in patients with diabetes. A new system was developed to grade the overall quality of the evidence and the strength of the recommendations. A draft of the guidelines was posted on the Internet, and the document was modified in response to comments. The guidelines were reviewed by the joint Evidence-Based Laboratory Medicine Committee of the AACC and the National Academy of Clinical Biochemistry and were accepted after revisions by the Professional Practice Committee and subsequent approval by the Executive Committee of the American Diabetes Association. In addition to the long-standing criteria based on measurement of venous plasma glucose, diabetes can be diagnosed by demonstrating increased hemoglobin A(1c) (Hb A(1c)) concentrations in the blood. Monitoring of glycemic control is performed by the patients measuring their own plasma or blood glucose with meters and by laboratory analysis of Hb A(1c). The potential roles of noninvasive glucose monitoring, genetic testing, and measurement of autoantibodies, urine albumin, insulin, proinsulin, C-peptide, and other analytes are addressed. The guidelines provide specific recommendations based on published data or derived from expert consensus. Several analytes are found to have minimal clinical value at the present time, and measurement of them is not recommended.

Glycated Hemoglobin A - analysis

Monitoring, Physiologic

Genetic Testing

Blood Glucose - analysis

Diabetes Mellitus - therapy

Humans

Disease Management

Diabetes Mellitus - diagnosis

Evidence-Based Medicine

Practice Guidelines as Topic

Details

Title: Subtitle: Executive summary: guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus
Creators: David B Sacks - Department of Laboratory Medicine, National Institutes of Health, Bethesda, MD 20892-1508, USA. sacksdb@mail.nih.gov
Mark Arnold
George L Bakris
David E Bruns
Andrea Rita Horvath
M Sue Kirkman
Ake Lernmark
Boyd E Metzger
David M Nathan
Resource Type: Journal article
Publication Details: Clinical chemistry (Baltimore, Md.), Vol.57(6), pp.793-1423
DOI: 10.1373/clinchem.2011.163634
PMID: 21617153
NLM abbreviation: Diabetes Care
ISSN: 0149-5992
eISSN: 1530-8561
Publisher: England
Grant note: name: ASL Analytical, Inc.; DOI: 10.13039/100004330, name: GlaxoSmithKline; DOI: 10.13039/100005632, name: Forest Laboratories; DOI: 10.13039/100004336, name: Novartis; DOI: 10.13039/501100004830, name: Siemens
Language: English
Date published: 06/2011
Academic Unit: Center for Biocatalysis and Bioprocessing; Fraternal Order of Eagles Diabetes Research Center; Chemistry
Record Identifier: 9983985874702771

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