Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases

Brad H. Rovin; Sharon G. Adler; Jonathan Barratt; Frank Bridoux; Kelly A. Burdge; Tak Mao Chan; H. Terence Cook; Fernando C. Fervenza; Keisha L. Gibson; Richard J. Glassock; David R.W. Jayne; Vivekanand Jha; Adrian Liew; Zhi-Hong Liu; Juan M. Mejía-Vilet; Carla M. Nester; Jai Radhakrishnan; Elizabeth M. Rave; Heather N. Reich; Pierre Ronco; Jan-Stephan F. Sanders; Sanjeev Sethi; Yusuke Suzuki; Sydney C.W. Tang; Vladimír Tesar; Marina Vivarelli; Jack F.M. Wetzels; Lyubov Lytvyn; Jonathan C. Craig; David J. Tunnicliffe; Martin Howell; Marcello A. Tonelli; Michael Cheung; Amy Earley; Jürgen Floege

doi:10.1016/j.kint.2021.05.015

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Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases

Journal article

Open access

Peer reviewed

Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases

Brad H. Rovin, Sharon G. Adler, Jonathan Barratt, Frank Bridoux, Kelly A. Burdge, Tak Mao Chan, H. Terence Cook, Fernando C. Fervenza, Keisha L. Gibson, Richard J. Glassock, …

Kidney international, Vol.100(4), pp.753-779

10/2021

DOI: 10.1016/j.kint.2021.05.015

PMID: 34556300

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Abstract

The Kidney Disease: Improving Global Outcomes (KDIGO) Clinical Practice Guideline for the Management of Glomerular Diseases is an update to the KDIGO 2012 guideline. The aim is to assist clinicians caring for individuals with glomerulonephritis (GN), both adults and children. The scope includes various glomerular diseases, including IgA nephropathy and IgA vasculitis, membranous nephropathy, nephrotic syndrome, minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), infection-related GN, antineutrophil cytoplasmic antibody (ANCA) vasculitis, lupus nephritis, and anti–glomerular basement membrane antibody GN. In addition, this guideline will be the first to address the subtype of complement-mediated diseases. Each chapter follows the same format providing guidance related to diagnosis, prognosis, treatment, and special situations. The goal of the guideline is to generate a useful resource for clinicians and patients by providing actionable recommendations based on evidence syntheses, with useful infographics incorporating views from experts in the field. Another aim is to propose research recommendations for areas where there are gaps in knowledge. The guideline targets a broad global audience of clinicians treating GN while being mindful of implications for policy and cost. Development of this guideline update followed an explicit process whereby treatment approaches and guideline recommendations are based on systematic reviews of relevant studies, and appraisal of the quality of the evidence and the strength of recommendations followed the “Grading of Recommendations Assessment, Development and Evaluation” (GRADE) approach. Limitations of the evidence are discussed, with areas of future research also presented.

AAV

ANCA

anti-GBM

complement

evidence-based

FSGS

glomerular diseases

glomerulonephritis

guideline

IgA nephropathy

IgA vasculitis

infection-related glomerulonephritis

KDIGO

lupus nephritis

membranous nephropathy

minimal change disease

MPGN

nephrotic syndrome

systematic review

Details

Title: Subtitle: Executive summary of the KDIGO 2021 Guideline for the Management of Glomerular Diseases
Creators: Brad H. Rovin - The Ohio State University
Sharon G. Adler - The Lundquist Institute
Jonathan Barratt - University of Leicester
Frank Bridoux - Centre Hospitalier Universitaire de Poitiers
Kelly A. Burdge - Salem Hospital
Tak Mao Chan - University of Hong Kong
H. Terence Cook - Imperial College London
Fernando C. Fervenza - Mayo Clinic
Keisha L. Gibson - University of North Carolina at Chapel Hill
Richard J. Glassock - University of California, Los Angeles
David R.W. Jayne - University of Cambridge
Vivekanand Jha - George Institute for Global Health
Adrian Liew - Mount Elizabeth Novena Hospital
Zhi-Hong Liu - Nanjing University
Juan M. Mejía-Vilet - Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Carla M. Nester - University of Iowa
Jai Radhakrishnan - Columbia University Irving Medical Center
Elizabeth M. Rave - Kidney Associates
Heather N. Reich - University of Toronto
Pierre Ronco - Sorbonne Université
Jan-Stephan F. Sanders - University of Groningen
Sanjeev Sethi - Mayo Clinic
Yusuke Suzuki - Juntendo University
Sydney C.W. Tang - University of Hong Kong
Vladimír Tesar - Charles University
Marina Vivarelli - Bambino Gesù Children's Hospital
Jack F.M. Wetzels - Radboud University Nijmegen
Lyubov Lytvyn - McMaster University
Jonathan C. Craig - Flinders University
David J. Tunnicliffe - Sydney Local Health District
Martin Howell - Sydney Local Health District
Marcello A. Tonelli - University of Calgary
Michael Cheung - KDIGO, Brussels, Belgium.
Amy Earley - KDIGO, Brussels, Belgium.
Jürgen Floege - Division of Nephrology, University Hospital, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen, Aachen, Germany
Resource Type: Journal article
Publication Details: Kidney international, Vol.100(4), pp.753-779
Publisher: Elsevier Inc
DOI: 10.1016/j.kint.2021.05.015
PMID: 34556300
ISSN: 0085-2538
eISSN: 1523-1755
Language: English
Date published: 10/2021
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Internal Medicine
Record Identifier: 9984353948802771

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