Exercise and Hippocampal Memory Systems

Michelle W Voss; Carmen Soto; Seungwoo Yoo; Matthew Sodoma; Carmen Vivar; Henriette van Praag

doi:10.1016/j.tics.2019.01.006

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Exercise and Hippocampal Memory Systems

Michelle W Voss, Carmen Soto, Seungwoo Yoo, Matthew Sodoma, Carmen Vivar and Henriette van Praag

Trends in cognitive sciences, Vol.23(4), pp.318-333

04/2019

DOI: 10.1016/j.tics.2019.01.006

PMCID: PMC6422697

PMID: 30777641

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Abstract

No medications prevent or reverse age-related cognitive decline. Physical activity (PA) enhances memory in rodents, but findings are mixed in human studies. As a result, exercise guidelines specific for brain health are absent. Here, we re-examine results from human studies, and suggest the use of more sensitive tasks to evaluate PA effects on age-related changes in the hippocampus, such as relational memory and mnemonic discrimination. We discuss recent advances from rodent and human studies into the underlying mechanisms at both the central and peripheral levels, including neurotrophins and myokines that could contribute to improved memory. Finally, we suggest guidelines for future research to help expedite well-founded PA recommendations for the public. A sedentary lifestyle increases the risk of memory deterioration and Alzheimer’s disease. Unfortunately, there is no treatment for memory decline. However, PA benefits rodent hippocampus-dependent memory through cellular mechanisms likely conserved in humans. Translating the promise of PA to human memory improvement or maintenance has been challenging and the best modes of activity and cognitive outcomes remain unclear. We propose a cross-species approach to bring insight to sensitive hippocampal memory tasks and a mechanistic foundation for PA-induced memory improvement.

hippocampus

growth factors

neurogenesis

pattern separation

myokines

aging

relational memory

physical activity

Details

Title: Subtitle: Exercise and Hippocampal Memory Systems
Creators: Michelle W Voss - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA
Carmen Soto - Laboratory of Neurogenesis and Neuroplasticity, Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
Seungwoo Yoo - Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA
Matthew Sodoma - Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA
Carmen Vivar - Laboratory of Neurogenesis and Neuroplasticity, Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico
Henriette van Praag - Department of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA
Resource Type: Journal article
Publication Details: Trends in cognitive sciences, Vol.23(4), pp.318-333
DOI: 10.1016/j.tics.2019.01.006
PMID: 30777641
PMCID: PMC6422697
NLM abbreviation: Trends Cogn Sci
ISSN: 1364-6613
eISSN: 1879-307X
Publisher: Elsevier Ltd
Grant note: DOI: 10.13039/501100003141, name: Consejo Nacional de Ciencia y Tecnología, award: INFR-2016 268247; DOI: 10.13039/501100010292, name: Fundación Miguel Alemán, A.C.; DOI: 10.13039/100000049, name: National Institute on Aging; DOI: 10.13039/100000057, name: National Institute of General Medical Sciences, award: RO1 AG055500, T32 GM108540
Language: English
Date published: 04/2019
Academic Unit: Radiology; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002484402771

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