Journal article
Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve
European journal of applied physiology, Vol.108(3), pp.459-468
02/01/2010
DOI: 10.1007/s00421-009-1232-1
PMID: 19830451
Abstract
The role of exercise training on hemodynamic parameters, blood lipid profiles, inflammatory cytokines, cholinesterase-positive nerves and muscarinic cholinergic (M-2) receptors expression in the heart was investigated in Sprague-Dawley male rats with hyperlipidemia (HL). The rats were subjected to a high-fat diet and exercise training for 8 weeks, and then the hemodynamic parameters, the profiles of blood lipid and inflammatory cytokines, and the expression of cholinesterase-positive nerves and M-2 receptors were measured. HL rats displayed cardiac dysfunction, dysregulation of inflammatory cytokines, and decreased cholinesterase-positive nerves and M-2 receptors expression. The combination of hyperlipidemia with exercise training (AT) restored the profiles of blood lipids and the levels of inflammatory cytokines. In addition, AT and HL + AT improved cardiac function with increasing cholinesterase-positive nerves and M-2 receptors expression. Overall, these data show that the increased expression of cholinesterase-positive nerves and M-2 receptors in the heart is partially responsible for the benefits of exercise training on cardiac function in hyperlipidemia rats.
Details
- Title: Subtitle
- Exercise benefits cardiovascular health in hyperlipidemia rats correlating with changes of the cardiac vagus nerve
- Creators
- You-Hua Wang - Xi'an Jiaotong UniversityHao Hu - Xi'an Jiaotong UniversitySheng-Peng Wang - Xi'an Jiaotong UniversityZhen-Jun Tian - Shaanxi Normal UniversityQuan-Jiang Zhang - Shaanxi Normal UniversityQiu-Xia Li - Shaanxi Normal UniversityYou-You Li - Shaanxi Normal UniversityXiao-Jiang Yu - Xi'an Jiaotong UniversityLei Sun - Xi'an Jiaotong UniversityDong-Ling Li - Xi'an Jiaotong UniversityBing Jia - Xi'an Jiaotong UniversityBing-Hang Liu - Xi'an Jiaotong UniversityWei-Jin Zang - Xi'an Jiaotong University
- Resource Type
- Journal article
- Publication Details
- European journal of applied physiology, Vol.108(3), pp.459-468
- Publisher
- Springer Nature
- DOI
- 10.1007/s00421-009-1232-1
- PMID
- 19830451
- ISSN
- 1439-6319
- eISSN
- 1439-6327
- Number of pages
- 10
- Grant note
- F510000/G16916404 / CMB Distinguished Professorships 2007CB512005 / National Basic Research Program of China 30930105; 30873058; 30770785 / National Natural Science Foundation of China; National Natural Science Foundation of China (NSFC)
- Language
- English
- Date published
- 02/01/2010
- Academic Unit
- Cardiovascular Medicine; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359806402771
Metrics
8 Record Views