Journal article
Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial
Contemporary clinical trials, Vol.145, 107647
10/2024
DOI: 10.1016/j.cct.2024.107647
PMCID: PMC11438497
PMID: 39095013
Abstract
Despite evidence that aerobic exercise benefits the aging brain, in particular the hippocampus and memory, controlled clinical trials have not comprehensively evaluated effects of aerobic exercise training on human memory in older adults. The central goal of this study was to determine chronic effects of moderate-to-vigorous intensity aerobic exercise on the hippocampus and memory in non-demented, inactive adults ages 55–80 years. We determine effects of aerobic exercise training with a 6-month randomized controlled trial (RCT) comparing 150 min/week of home-based, light intensity exercise with progressive moderate-to-vigorous intensity aerobic exercise. For the first time in a large trial, we examined temporal mechanisms by determining if individual differences in the rapid, immediate effects of moderate intensity exercise on hippocampal-cortical connectivity predict chronic training-related changes over months in connectivity and memory. We examined physiological mechanisms by testing the extent to which chronic training-related changes in cardiorespiratory fitness are a critical factor to memory benefits. The Exercise Effects on Brain Connectivity and Learning from Minutes to Months (Brain-EXTEND) trial is conceptually innovative with advanced measures of hippocampal-dependent learning and memory processes combined with novel capture of the physiological changes, genetic components, and molecular changes induced by aerobic exercise that change hippocampal-cortical connectivity. Given that hippocampal connectivity deteriorates with Alzheimer's and aerobic exercise may contribute to reduced risk of Alzheimer's, our results could lead to an understanding of the physiological mechanisms and moderators by which aerobic exercise reduces risk of this devastating and costly disease.
Details
- Title: Subtitle
- Exercise effects on brain health and learning from minutes to months: The brain EXTEND trial
- Creators
- Michelle W. Voss - University of IowaChris Oehler - University of IowaWill Daniels - University of IowaMatthew Sodoma - University of IowaBryan Madero - University of IowaJames Kent - University of IowaShivangi Jain - University of IowaMyungjin Jung - University of IowaVirginia R. Nuckols - University of IowaLyndsey E. DuBose - University of IowaKristen G. Davis - University of IowaAbby O'Deen - Department of Psychological and Brain Sciences, College of Liberal Arts and Sciences, The University of Iowa, USAChase Hamilton - University of IowaKelsey Baller - University of IowaJenna Springer - University of IowaAdriana Rivera-Dompenciel - University of IowaMarco Pipoly - University of IowaMichael Muellerleile - University of IowaNagalakshmi Nagarajan - University of IowaThorarinn Bjarnason - University of IowaNidal Harb - University of IowaLi-Chun Lin - University of IowaVincent Magnotta - University of IowaEliot Hazeltine - University of IowaJeffrey D. Long - University of IowaGary L. Pierce - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.145, 107647
- DOI
- 10.1016/j.cct.2024.107647
- PMID
- 39095013
- PMCID
- PMC11438497
- NLM abbreviation
- Contemp Clin Trials
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Publisher
- Elsevier Inc
- Grant note
- National Institute of General Medical Sciences (NIGMS): T32 GM108540 National Institute on Aging (NIA): R01 AG055500 High-end instrumentation grant: S10OD025025
We thank the support from the National Institute of General Medical Sciences (NIGMS) (T32 GM108540) , National Institute on Aging (NIA) (R01 AG055500) , the Iowa Neuroscience Institute Williams-Cannon Fellowship (blood-based biomarkers and genomics) , MR imaging on equipment supported by a high-end instrumentation grant (S10OD025025) and the Russell B. Day and Florence D. Day Endowed Chair in Liberal Arts and Sciences at the University of Iowa supports Gary Pierce. We also thank Trevor Lee Cline, Taylor Sloan, Eleanor Henry, Jillian Kousins, Keely Paus, Ellen Slattery, Tuan Truong, Pinar Emirahmetoglu, Bailey Hollis, Amy Stroud, Colin Gimblet, Matthew Armstrong, and Grace Foster for their valuable contributions to data collection and data entry. We thank the Data and Safety Monitoring Board (DSMB) for their oversight of the trial: Dr. Michael Marsiske (University of Florida) , Dr. Jeffrey Burns (University of Kansas) , and Dr. Charles Hall (Albert Einstein College of Medicine) .
- Language
- English
- Electronic publication date
- 07/31/2024
- Date published
- 10/2024
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Cardiovascular Medicine; Neuroscience and Pharmacology; Health, Sport, and Human Physiology ; Internal Medicine
- Record Identifier
- 9984693979802771
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