Journal article
Exercise haemodynamic effects of beta-blockade and intrinsic sympathomimetic activity
European journal of clinical pharmacology, Vol.36(1), pp.5-10
1989
DOI: 10.1007/BF00561015
PMID: 2917588
Abstract
Beta-adrenergic blockade with intrinsic sympathomimetic activity (ISA) causes less depression of resting and submaximal heart rate (HR) than non-ISA beta-blockers. The effects of these drugs on exercise haemodynamics have not been well studied. We evaluated effects of pindolol, propranolol and placebo during rest and steady-state exercise on cardiac output, oxygen consumption, calf blood flow, HR and blood pressure in 18 healthy subjects.
Pindolol 5 mg and propranolol 80 mg given twice daily, reduced maximal exercise HR by 50 and 52 beats·min−1 respectively, confirming similarity of beta1-blockade. Resting cardiac output was unchanged in all three groups after one week of therapy.
Cardiac output, measured during steady-state exercise decreased in the propranolol group (18.3 vs 15.6 l·min−1) with no significant changes in pindolol (15.7 vs 16.0 l·min−1) or placebo (18.6 vs 17.3 l·min−1). The rise in cardiac output, from rest to exercise, was similarly attenuated by propranolol but not by pindolol or placebo. Exercise stroke volume increased 12% on pindolol (123–140 cc) and decreased 7% on propranolol (143–133 cc).
Neither drug had a detrimental effect on exercise calf blood flow compared to placebo. Thus, unlike propranolol, pindolol with ISA, maintains a normal cardiac output during submaximal exercise.
Details
- Title: Subtitle
- Exercise haemodynamic effects of beta-blockade and intrinsic sympathomimetic activity
- Creators
- P. A Ades - University of Vermont Medical CenterE. E Wolfel - University of Colorado HealthW. R Hiatt - University of Colorado HealthC Fee - University of Colorado HealthR Rolfs - University of Colorado HealthH. L Brammell - University of Colorado HealthL. D Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- European journal of clinical pharmacology, Vol.36(1), pp.5-10
- Publisher
- Springer
- DOI
- 10.1007/BF00561015
- PMID
- 2917588
- ISSN
- 0031-6970
- eISSN
- 1432-1041
- Language
- English
- Date published
- 1989
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656532602771
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