Journal article
Exercise-induced Bronchoconstriction: Reproducibility of Hyperpolarized He-3 MR Imaging
Radiology, Vol.266(2), pp.618-625
02/01/2013
DOI: 10.1148/radiol.12111973
PMCID: PMC5411018
PMID: 23169798
Abstract
Purpose: To quantitatively evaluate interday, interreader, and intersite agreement of readers of hyperpolarized helium 3 (HPHe) MR images in patients with exercise-induced bronchoconstriction.
Materials and Methods: This HIPAA-compliant, institutional review board approved study included 13 patients with exercise-induced bronchoconstriction. On two separate days, HPHe MR imaging of the lungs was performed at baseline, immediately after a 10-minute exercise challenge (postchallenge), and 45 minutes after exercise (recovery). Patients were imaged at two sites, six at site A and seven at site B. Images were analyzed independently by multiple readers at each site. Lung volume, ventilation defect volume, ventilated volume, and the number of defects were measured quantitatively, and the location of defects was evaluated qualitatively at site A. Interday and interreader agreement were evaluated by using the intraclass correlation coefficient (ICC), and intersite agreement was evaluated by using a modified Bland-Altman analysis.
Results: The ICC between days for ventilation defect volume, ventilated volume, and number of defects was at least 0.74 at both sites. The ICC for lung volume was greater at site B (0.83-0.86) than at site A (0.60-0.65). Defects seen in the same location in the lung on both days included 19.7% of those seen on baseline images and 29.2% and 18.6% of defects on postchallenge and recovery images, respectively. Interreader ICC for each measurement was at least 0.82 for each site. Analysis of intersite agreement showed biases of 612 mL for lung volume, 260.7 mL for ventilation defect volume, 2.91% for ventilated volume, and 26.56 for number of defects.
Conclusion: The reported measures of reproducibility of HPHe MR imaging may help in the design and interpretation of single- and multicenter studies of patients with exercise-induced bronchoconstriction. (C) RSNA, 2012
Details
- Title: Subtitle
- Exercise-induced Bronchoconstriction: Reproducibility of Hyperpolarized He-3 MR Imaging
- Creators
- David J. Niles - University of Wisconsin–MadisonStanley J. Kruger - Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USABernard J. Dardzinski - Merck Res Labs, West Point, PA USAAmy Harman - Merck Res Labs, West Point, PA USANizar N. Jarjour - University of Wisconsin–MadisonMarcella Ruddy - Merck Res Labs, West Point, PA USAScott K. Nagle - Univ Wisconsin, Dept Radiol, Madison, WI 53705 USAChristopher J. Francois - Univ Wisconsin, Dept Radiol, Madison, WI 53705 USASean B. Fain - Univ Wisconsin, Dept Med Phys, Madison, WI 53705 USA
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.266(2), pp.618-625
- DOI
- 10.1148/radiol.12111973
- PMID
- 23169798
- PMCID
- PMC5411018
- NLM abbreviation
- Radiology
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Publisher
- Radiological Soc North America
- Number of pages
- 8
- Grant note
- UL1TR000427 / NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) National Heart, Lung, and Blood Institute; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA M01RR003186 / NATIONAL CENTER FOR RESEARCH RESOURCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Research Resources (NCRR) Merck; Merck & Company
- Language
- English
- Date published
- 02/01/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274955002771
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