Journal article
Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation
Pain (Amsterdam), Vol.159 Suppl 1(9), pp.S91-S97
09/2018
DOI: 10.1097/j.pain.0000000000001235
PMCID: PMC6097240
PMID: 30113953
Abstract
An acute bout of physical activity and exercise can increase pain in individuals with chronic pain, but regular exercise is an effective treatment. This review will discuss these two dichotomous findings by summarizing studies in human and animal subjects. We will provide the data that supports the role of physical activity in modulating central nervous system excitability and inhibition, immune system function, and psychological constructs associated with pain. We show evidence that the sedentary condition is associated with greater excitability and less inhibition in both the central nervous system (brainstem inhibitory/facilitatory sites) and the immune system. We further show that exercise and regular physical activity decreases excitability and improves inhibition in both the central nervous system (brainstem inhibitory/facilitatory sites) and the immune system. We will then discuss the clinical implications of these findings, make recommendations for clinical application of exercise, and suggest future research directions.
Details
- Title: Subtitle
- Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation
- Creators
- Kathleen A Sluka - Pain Research Program, The University of Iowa, Iowa City, IA, United StatesLaura Frey-Law - Department of Physical Therapy and Rehabilitation Science, The University of Iowa, Iowa City, IA, United StatesMarie Hoeger Bement - Department of Physical Therapy, Marquette University, Milwaukee, WI, United States
- Resource Type
- Journal article
- Publication Details
- Pain (Amsterdam), Vol.159 Suppl 1(9), pp.S91-S97
- DOI
- 10.1097/j.pain.0000000000001235
- PMID
- 30113953
- PMCID
- PMC6097240
- NLM abbreviation
- Pain
- ISSN
- 0304-3959
- eISSN
- 1872-6623
- Publisher
- United States
- Grant note
- R01 AR061371 / NIAMS NIH HHS R03 AR065197 / NIAMS NIH HHS UM1 AR063381 / NIAMS NIH HHS
- Language
- English
- Date published
- 09/2018
- Academic Unit
- Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
- Record Identifier
- 9984040388902771
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