Journal article
Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure
Experimental physiology, Vol.109(4), pp.502-512
04/01/2024
DOI: 10.1113/EP090674
PMCID: PMC10984794
PMID: 38063130
Abstract
Heart failure with preserved ejection fraction (HFpEF) accounts for over 50% of all heart failure cases nationwide and continues to rise in its prevalence. The complex, multi‐organ involvement of the HFpEF clinical syndrome requires clinicians and investigators to adopt an integrative approach that considers the contribution of both cardiac and non‐cardiac function to HFpEF pathophysiology. Thus, this symposium review outlines the key points from presentations covering the contributions of disease‐related changes in cardiac function, arterial stiffness, peripheral vascular function, and oxygen delivery and utilization to exercise tolerance in patients with HFpEF. While many aspects of HFpEF pathophysiology remain poorly understood, there is accumulating evidence for a decline in vascular health in this patient group that may be remediable through pharmacological and lifestyle interventions and could improve outcomes and clinical status in this ever‐growing patient population.
What is the topic of this review?
This symposium review provides an integrative view of how disease‐related changes in cardiac, vascular and skeletal muscle function contribute to exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF).
What advances does it highlight?
Emerging evidence continues to highlight the importance of considering both cardiac and non‐cardiac abnormalities in patients with HFpEF, with accumulating evidence for ‘plasticity’ in vascular function that emphasizes the need for a greater focus on strategies targeting the peripheral circulation as a means to improve exercise intolerance.
Details
- Title: Subtitle
- Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure
- Creators
- Kanokwan Bunsawat - Geriatric Research Education and Clinical CenterMichael D. Nelson - The University of Texas at ArlingtonChristopher M. Hearon - The University of Texas Southwestern Medical CenterD. Walter Wray - University of Utah
- Resource Type
- Journal article
- Publication Details
- Experimental physiology, Vol.109(4), pp.502-512
- DOI
- 10.1113/EP090674
- PMID
- 38063130
- PMCID
- PMC10984794
- NLM abbreviation
- Exp Physiol
- ISSN
- 0958-0670
- eISSN
- 1469-445X
- Publisher
- John Wiley and Sons Inc
- Number of pages
- 11
- Language
- English
- Date published
- 04/01/2024
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984948042102771
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