Exercise training improves endothelial function in young prehypertensives

Darren T Beck; Darren P Casey; Jeffrey S Martin; Blaze D Emerson; Randy W Braith

doi:10.1177/1535370213477600

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Exercise training improves endothelial function in young prehypertensives

Journal article

Open access

Peer reviewed

Exercise training improves endothelial function in young prehypertensives

Darren T Beck, Darren P Casey, Jeffrey S Martin, Blaze D Emerson and Randy W Braith

Experimental biology and medicine (Maywood, N.J.), Vol.238(4), pp.433-441

04/2013

DOI: 10.1177/1535370213477600

PMCID: PMC4457439

PMID: 23760009

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Abstract

Prehypertensives exhibit marked endothelial dysfunction, a risk factor for future cardiovascular morbidity and mortality. However, the ability of exercise to ameliorate endothelial dysfunction in prehypertensives is grossly underinvestigated. This prospective randomized and controlled study examined the separate effects of resistance and endurance training on conduit artery endothelial function in young prehypertensives. Forty-three unmedicated prehypertensive (systolic blood pressure [SBP]=120–139 mmHg; diastolic blood pressure [DBP]=80–89 mmHg) but otherwise healthy men and women and 15 normotensive matched time-controls (NMTC); n = 15) between 18 and 35 y of age met screening requirements and participated in the study. Prehypertensive subjects were randomly assigned to either a resistance exercise training (PHRT; n = 15), endurance exercise training (PHET; n = 13) or time-control group (PHTC; n = 15). The treatment groups performed exercise training three days per week for eight weeks. The control groups did not initiate exercise programs throughout the study. Flow mediated dilation (FMD) of the brachial artery, biomarkers of enodothelial function and peripheral blood pressure were evaluated before and after exercise intervention or time-matched control. PHRT and PHET reduced resting SBP (9.6 ± 3.6 and 11.9 ± 3.4 mmHg, respectively; P < 0.05) and DBP (8.0 ± 5.1 and 7.2 ± 3.4 mmHg, respectively; P < 0.05). Exercise training improved brachial artery FMD absolute diameter, percent dilation and normalized percent dilation by 30%, 34% and 19% for PHRT, P < 0.05; and by 54%, 63% and 75% for PHET, P < 0.05; respectively. PHRT and PHET increased plasma concentrations of 6-keto prostaglandin F1 α (19% and 22%, respectively; P < 0.05), NO x (19% and 23%, respectively; P < 0.05), and reduced endothelin-1 by (16% and 24%, respectively; P < 0.01). This study provides novel evidence that resistance and endurance exercise separately have beneficial effects on resting peripheral blood pressure, brachial artery FMD and endothelial-derived vasoactive agents in young prehypertensives.

endothelial function

endothelin

exercise

nitric-oxide

prehypertension

Details

Title: Subtitle: Exercise training improves endothelial function in young prehypertensives
Creators: Darren T Beck - Malcom Randall VA Medical Center, GRECC, Gainesville, FL 32601
Darren P Casey - Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905
Jeffrey S Martin - Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Blaze D Emerson - Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Randy W Braith - Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL 32611, USA
Resource Type: Journal article
Publication Details: Experimental biology and medicine (Maywood, N.J.), Vol.238(4), pp.433-441
DOI: 10.1177/1535370213477600
PMID: 23760009
PMCID: PMC4457439
NLM abbreviation: Exp Biol Med (Maywood)
ISSN: 1535-3702
eISSN: 1535-3699
Language: English
Date published: 04/2013
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984047887102771

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