Journal article
Exogenous Dp71 restores the levels of dystrophin associated proteins but does not alleviate muscle damage in mdx mice
Nature genetics, Vol.8(4), pp.340-344
12/1994
DOI: 10.1038/ng1294-340
PMID: 7894483
Abstract
Dp71 is a non-muscle product of the Duchenne muscular dystrophy gene. It consists of the cysteine-rich and C-terminal domains of dystrophin. We have generated transgenic mdx mice which do not have dystrophin but express Dp71 in their muscle. In these mice, Dp71 was localized to the plasma membrane and restored normal levels of dystrophin associated protiens (DAPs), indicating that Dp71 is capable of interacting with the DAPs in a similar manner to dystrophin. However, the presence of Dp71 and DAPs in the muscle fibres of mdx mice was not sufficient to alleviate symptoms of muscle degeneration.
Details
- Title: Subtitle
- Exogenous Dp71 restores the levels of dystrophin associated proteins but does not alleviate muscle damage in mdx mice
- Creators
- David S GreenbergYoshihide SunadaKevin P CampbellDavid YaffeUri Nudel
- Resource Type
- Journal article
- Publication Details
- Nature genetics, Vol.8(4), pp.340-344
- DOI
- 10.1038/ng1294-340
- PMID
- 7894483
- ISSN
- 1061-4036
- eISSN
- 1546-1718
- Language
- English
- Date published
- 12/1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute
- Record Identifier
- 9984020895502771
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