Exogenous sex hormone use, correlates of endogenous hormone levels, and the incidence of histologic types of sarcoma of the uterus

Stephen M Schwartz; Noel S Weiss; Janet R Daling; Marilie D Gammon; Jonathan M Liff; Jan Watt; Charles F Lynch; Polly A Newcomb; Bruce K Armstrong; W Douglas Thompson

doi:10.1002/(SICI)1097-0142(19960215)77:4<717::AID-CNCR18>3.0.CO;2-3

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Exogenous sex hormone use, correlates of endogenous hormone levels, and the incidence of histologic types of sarcoma of the uterus

Journal article

Open access

Peer reviewed

Exogenous sex hormone use, correlates of endogenous hormone levels, and the incidence of histologic types of sarcoma of the uterus

Stephen M Schwartz, Noel S Weiss, Janet R Daling, Marilie D Gammon, Jonathan M Liff, Jan Watt, Charles F Lynch, Polly A Newcomb, Bruce K Armstrong and W Douglas Thompson

Cancer, Vol.77(4), pp.717-724

02/15/1996

DOI: 10.1002/(SICI)1097-0142(19960215)77:4<717::AID-CNCR18>3.0.CO;2-3

PMID: 8616764

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https://doi.org/10.1002/(SICI)1097-0142(19960215)77:4<717::AID-CNCR18>3.0.CO;2-3View

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Abstract

We analyzed data from a population-based, multi-center, case-control study to determine whether the occurrence of histologic types of uterine sarcoma is related to exogenous hormone use and/or to two correlates of endogenous estrogens: excess weight and cigarette smoking. One hundred sixty-seven women with newly-diagnosed uterine sarcoma (56 leiomyosarcoma, 85 mixed mullerian tumors, and 26 endometrial stromal sarcomas) were interviewed by telephone regarding possible risk factors for these neoplasms, For comparison, 208 women identified at random from the general population of the study areas were interviewed as controls. Use of oral contraceptives was positively associated with the risk of leiomyosarcoma (odds ratios [OR] = 1.7, 95% confidence interval [CI] = 0.7, 4.1), primarily among women who last used these medications 15 or more years prior to diagnosis. Use of noncontraceptive estrogens was directly associated with the risk of mixed mullerian tumors, but only among recent and long-term users of these medications. Women in the highest quantile of body mass index (> or = 27.5 kg/m2) one year prior to diagnosis were at increased risk of each type of uterine sarcoma (leiomyosarcoma, OR = 2.5, 95% CI = 1.1, 5.7; mixed mullerian tumors, OR = 2.9, 95% CI = 1.3, 6.7; stromal sarcoma, OR = 3.5, 95% CI = 1.1, 10.9). Women who had ever smoked cigarettes were at reduced risk of leiomyosarcoma (OR = 0.6, 95% CI = 0.3, 1.1) and stromal sarcoma (OR = 0.5, 95% CI = 0.2, 1.2), but the relationship was not more pronounced among heavy smokers; no association with smoking was observed with mixed mullerian tumors. Several of these findings parallel those from studies of endometrial carcinoma and may indicate a role for unopposed estrogen in the etiology of histologic types of uterine sarcoma.

Menopause

Obesity

United States - epidemiology

Confidence Intervals

Mixed Tumor, Mullerian - epidemiology

Age Factors

Telephone

Uterine Neoplasms - pathology

Estrogens

Humans

Middle Aged

Uterine Neoplasms - epidemiology

Reference Values

Socioeconomic Factors

Incidence

Leiomyosarcoma - epidemiology

Contraceptives, Oral

Adult

Female

Interviews as Topic

Odds Ratio

Body Mass Index

Leiomyosarcoma - pathology

Risk Factors

Endometrial Neoplasms - epidemiology

Sarcoma - pathology

Mixed Tumor, Mullerian - pathology

Adolescent

Endometrial Neoplasms - pathology

Aged

Sarcoma - epidemiology

Western Australia - epidemiology

Cohort Studies

Smoking

Details

Title: Subtitle: Exogenous sex hormone use, correlates of endogenous hormone levels, and the incidence of histologic types of sarcoma of the uterus
Creators: Stephen M Schwartz - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Noel S Weiss
Janet R Daling
Marilie D Gammon
Jonathan M Liff
Jan Watt
Charles F Lynch
Polly A Newcomb
Bruce K Armstrong
W Douglas Thompson
Resource Type: Journal article
Publication Details: Cancer, Vol.77(4), pp.717-724
Publisher: United States
DOI: 10.1002/(SICI)1097-0142(19960215)77:4<717::AID-CNCR18>3.0.CO;2-3
PMID: 8616764
ISSN: 0008-543X
eISSN: 1097-0142
Grant note: N01-CN-05230 / NCI NIH HHS R35CA-39779 / NCI NIH HHS
Language: English
Date published: 02/15/1996
Academic Unit: Epidemiology
Record Identifier: 9983996082402771

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