Journal article
Exotoxins of Staphylococcus aureus
Clinical microbiology reviews, Vol.13(1), pp.16-34
01/2000
DOI: 10.1128/cmr.13.1.16
PMID: 10627489
Abstract
This article reviews the literature regarding the structure and function of two types of exotoxins expressed by Staphylococcus aureus, pyrogenic toxin superantigens (PTSAgs) and hemolysins. The molecular basis of PTSAg toxicity is presented in the context of two diseases known to be caused by these exotoxins: toxic shock syndrome and staphylococcal food poisoning. The family of staphylococcal PTSAgs presently includes toxic shock syndrome toxin-1 (TSST-1) and most of the staphylococcal enterotoxins (SEs) (SEA, SEB, SEC, SED, SEE, SEG, and SEH). As the name implies, the PTSAgs are multifunctional proteins that invariably exhibit lethal activity, pyrogenicity, superantigenicity, and the capacity to induce lethal hypersensitivity to endotoxin. Other properties exhibited by one or more staphylococcal PTSAgs include emetic activity (SEs) and penetration across mucosal barriers (TSST-1). A detailed review of the molecular mechanisms underlying the toxicity of the staphylococcal hemolysins is also presented.
Details
- Title: Subtitle
- Exotoxins of Staphylococcus aureus
- Creators
- Martin M Dinges - Department of Microbiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455Paul M Orwin - Department of Microbiology, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455Patrick M Schlievert - University of Iowa, Microbiology and Immunology
- Resource Type
- Journal article
- Publication Details
- Clinical microbiology reviews, Vol.13(1), pp.16-34
- Publisher
- American Society for Microbiology
- DOI
- 10.1128/cmr.13.1.16
- PMID
- 10627489
- ISSN
- 0893-8512
- eISSN
- 1098-6618
- Language
- English
- Date published
- 01/2000
- Academic Unit
- Microbiology and Immunology; Internal Medicine
- Record Identifier
- 9984001791002771
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