Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Mitchell N Lefebvre; Fionna A Surette; Scott M Anthony; Rahul Vijay; Isaac J Jensen; Lecia L Pewe; Lisa S Hancox; Natalija Van Braeckel-Budimir; Stephanie van de Wall; Stina L Urban; Madison R Mix; Samarchith P Kurup; Vladimir P Badovinac; Noah S Butler; John T Harty

doi:10.1016/j.celrep.2021.109956

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Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Journal article

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Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria

Mitchell N Lefebvre, Fionna A Surette, Scott M Anthony, Rahul Vijay, Isaac J Jensen, Lecia L Pewe, Lisa S Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L Urban, …

Cell reports (Cambridge), Vol.37(5), 109956

11/2021

DOI: 10.1016/j.celrep.2021.109956

PMCID: PMC8628427

PMID: 34731605

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Abstract

Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infections and mediate pathogen clearance. Tem recruitment coincides with rapid transcriptional upregulation of inflammatory genes in Plasmodium-infected livers. Recruitment requires CD8 T cell-intrinsic LFA-1 expression and the presence of liver phagocytes. Rapid Tem liver infiltration is distinct from recruitment to other non-lymphoid tissues in that it occurs both in the absence of liver tissue resident memory "sensing-and-alarm" function and ∼42 hours earlier than in lung infection by influenza virus. These data demonstrate relevance for Tem in protection against malaria and provide generalizable mechanistic insights germane to control of liver infections. Keywords: CD8 T cells; liver-stage immunity; malaria. Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.

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Title: Subtitle: Expeditious recruitment of circulating memory CD8 T cells to the liver facilitates control of malaria
Creators: Mitchell N Lefebvre
Fionna A Surette
Scott M Anthony
Rahul Vijay
Isaac J Jensen
Lecia L Pewe
Lisa S Hancox
Natalija Van Braeckel-Budimir
Stephanie van de Wall
Stina L Urban
Madison R Mix
Samarchith P Kurup
Vladimir P Badovinac
Noah S Butler
John T Harty
Resource Type: Journal article
Publication Details: Cell reports (Cambridge), Vol.37(5), 109956
DOI: 10.1016/j.celrep.2021.109956
PMID: 34731605
PMCID: PMC8628427
NLM abbreviation: Cell Rep
ISSN: 2211-1247
eISSN: 2211-1247
Grant note: DOI: 10.13039/100000060, name: NIAID, award: AI100527, AI42767; DOI: 10.13039/100008893, name: University of Iowa, award: A125446, A127481, AI114543, AI985515, GM134880, T32 AI007511, T32 HL007; DOI: 10.13039/100000002, name: National Institutes of Health, award: P30 CA086862
Language: English
Date published: 11/2021
Academic Unit: Microbiology and Immunology; University of Iowa; Pathology
Record Identifier: 9984193555202771

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