Experience with Sequential Intravesical Gemcitabine and Docetaxel as Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Kyla Velaer; Ryan Steinberg; Lewis Thomas; Michael O’Donnell; Kenneth Nepple

doi:10.1007/s11934-016-0594-2

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Experience with Sequential Intravesical Gemcitabine and Docetaxel as Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Journal article

Peer reviewed

Experience with Sequential Intravesical Gemcitabine and Docetaxel as Salvage Therapy for Non-Muscle Invasive Bladder Cancer

Kyla Velaer, Ryan Steinberg, Lewis Thomas, Michael O’Donnell and Kenneth Nepple

Current urology reports, Vol.17(5), pp.1-5

05/2016

DOI: 10.1007/s11934-016-0594-2

PMID: 26968418

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Abstract

Patients with high-grade muscle invasive bladder cancer (NMIBC) receive intravesical therapy with bacillus Calmette-Guérin (BCG) as the well-established standard-of-care. However, even with prompt induction of intravesical therapy, approximately 40 % of patients will recur within 2 years. For patients who fail BCG, options include radical cystectomy, repeat BCG therapy, or alternative intravesical salvage therapy. In this review, we will discuss the most recent published evidence on salvage intravesical therapy with an emphasis on a more in-depth report of our therapeutic strategy with sequential gemcitabine and docetaxel intravesical therapy for this treatment-refractory population. In addition, we will provide practical advice on our approach to this challenging patient population including the use of operative staging to aid early identification of treatment failures.

Bacillus Calmette-Guérin

Nephrology

Urinary bladder neoplasms

Medicine & Public Health

Mycobacterium bovis

Gemcitabine

Docetaxel

Urology

Details

Title: Subtitle: Experience with Sequential Intravesical Gemcitabine and Docetaxel as Salvage Therapy for Non-Muscle Invasive Bladder Cancer
Creators: Kyla Velaer - Department of Urology University of Iowa 200 Hawkins Dr., 3 RCP Iowa City IA 52242-1089 USA
Ryan Steinberg - Department of Urology University of Iowa 200 Hawkins Dr., 3 RCP Iowa City IA 52242-1089 USA
Lewis Thomas - Department of Urology University of Iowa 200 Hawkins Dr., 3 RCP Iowa City IA 52242-1089 USA
Michael O’Donnell - Department of Urology University of Iowa 200 Hawkins Dr., 3 RCP Iowa City IA 52242-1089 USA
Kenneth Nepple - Department of Urology University of Iowa 200 Hawkins Dr., 3 RCP Iowa City IA 52242-1089 USA
Resource Type: Journal article
Publication Details: Current urology reports, Vol.17(5), pp.1-5
Publisher: Springer US; New York
DOI: 10.1007/s11934-016-0594-2
PMID: 26968418
ISSN: 1527-2737
eISSN: 1534-6285
Language: English
Date published: 05/2016
Academic Unit: Urology
Record Identifier: 9984051557302771

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