Journal article
Experience‐related enhancements in striatal temporal encoding
The European journal of neuroscience, Vol.54(3), pp.5063-5074
06/07/2021
DOI: 10.1111/ejn.15344
PMCID: PMC8511940
PMID: 34097793
Abstract
Temporal control of action is key for a broad range of behaviors and is disrupted in human diseases such as Parkinson's disease and schizophrenia. A brain structure that is critical for temporal control is the dorsal striatum. Experience and learning can influence dorsal striatal neuronal activity, but it is unknown how these neurons change with experience in contexts which require precise temporal control of movement. We investigated this question by recording from medium spiny neurons (MSNs) via dorsal striatal microelectrode arrays in mice as they gained experience controlling their actions in time. We leveraged an interval timing task optimized for mice which required them to "switch" response ports after enough time had passed without receiving a reward. We report three main results. First, we found that time-related ramping activity and response-related activity increased with task experience. Second, temporal decoding by MSN ensembles improved with experience and was predominantly driven by time-related ramping activity. Finally, we found that a subset of MSNs had differential modulation on error trials. These findings enhance our understanding of dorsal striatal temporal processing by demonstrating how MSN ensembles can evolve with experience. Our results can be linked to temporal habituation and illuminate striatal flexibility during interval timing, which may be relevant for human disease.
Details
- Title: Subtitle
- Experience‐related enhancements in striatal temporal encoding
- Creators
- R. Austin Bruce - Interdisciplinary Graduate Program in Neuroscience University of Iowa Iowa City 52242, Department of Neurology University of Iowa Iowa City 52242Matthew A Weber - Department of Neurology University of Iowa Iowa City 52242Rachael A Volkman - Department of Neurology University of Iowa Iowa City 52242Mayu Oya - Department of Neurology University of Iowa Iowa City 52242Eric B Emmons - Department of Biology Wartburg College Waverly 50677Youngcho Kim - Department of Neurology University of Iowa Iowa City 52242Nandakumar S Narayanan - Department of Neurology University of Iowa Iowa City 52242
- Resource Type
- Journal article
- Publication Details
- The European journal of neuroscience, Vol.54(3), pp.5063-5074
- DOI
- 10.1111/ejn.15344
- PMID
- 34097793
- PMCID
- PMC8511940
- NLM abbreviation
- Eur J Neurosci
- ISSN
- 0953-816X
- eISSN
- 1460-9568
- Grant note
- DOI: 10.13039/100005440, name: Center for Scientific Review, award: MH116043, UL1TR002537
- Language
- English
- Date published
- 06/07/2021
- Academic Unit
- Neurology; Iowa Neuroscience Institute
- Record Identifier
- 9984087708402771
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