Journal article
Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study
The Journal of urology, Vol.207(1), pp.161-171
01/2022
DOI: 10.1097/JU.0000000000002147
PMCID: PMC9237822
PMID: 34428922
Abstract
The objective of this study was to investigate the presence of nonbladder sensory abnormalities in participants with overactive bladder syndrome (OAB).
Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) study participants with OAB symptoms and controls were recruited from 6 U.S. tertiary referral centers. Quantitative sensory testing (QST) was performed to determine pressure pain sensitivity at the thumbnail bed and auditory sensitivity. Fixed and mixed effect multivariable linear regressions and Weibull models were used to compare QST responses between groups. Pearson correlations were used to assess the relationship between QST measures. Associations between QST and self-reported symptoms were explored with linear regression.
A total of 297 participants were analyzed (191 OAB, 106 controls; 76% white, 51% male). OAB cases were older than controls (57.4 vs 52.2 years, p=0.015). No significant differences in experimental thumbnail (nonbladder) pain or auditory sensitivity were detected between OAB cases and controls. Correlations between pressure and auditory derived metrics were weak to moderate overall for both groups, with some significantly stronger correlations for cases. Exploratory analyses indicated increased pressure pain and auditory sensitivity were modestly associated with greater self-reported bladder pain and pain interference with physical function.
As a group, no significant differences between OAB cases and controls were observed in experimental nonbladder pain or auditory sensitivity during QST. Associations between QST outcomes and clinical pain raise the possibility of centrally mediated sensory amplification in some individuals with OAB.
Details
- Title: Subtitle
- Experimental Pain and Auditory Sensitivity in Overactive Bladder Syndrome: A Symptoms of the Lower Urinary Tract Dysfunction Research Network (LURN) Study
- Creators
- Steven E Harte - University of MichiganJon Wiseman - Arbor Research Collaborative for HealthYing Wang - Indiana UniversityAbigail R Smith - Arbor Research Collaborative for HealthClaire C Yang - University of WashingtonMargaret Helmuth - Arbor Research Collaborative for HealthKarl Kreder - University of IowaGrant H Kruger - University of MichiganBrenda W Gillespie - Arbor Research Collaborative for HealthCindy Amundsen - Duke UniversityZiya Kirkali - National Institute of Diabetes and Digestive and Kidney DiseasesH Henry Lai - Washington University in St. LouisLURN Study Group
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.207(1), pp.161-171
- DOI
- 10.1097/JU.0000000000002147
- PMID
- 34428922
- PMCID
- PMC9237822
- NLM abbreviation
- J Urol
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Grant note
- U01 DK097780 / NIDDK NIH HHS U01 DK097779 / NIDDK NIH HHS U01 DK097772 / NIDDK NIH HHS
- Language
- English
- Date published
- 01/2022
- Academic Unit
- Obstetrics and Gynecology; Urology
- Record Identifier
- 9984383296402771
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