Experimental Study of Rupture Pressure and Elasticity of Abdominal Aortic Aneurysms Found at Autopsy

Vivian Carla Gomes; Madhavan Lakshmi Raghavan; Luiz Fernando Ferraz da Silva; Jorge Gomes; Gina Camillo Silvestre; Alexandre Queiroz; Michele Alberto Marques; Selene Perrotti Zyngier; Timothy Kwang-Joon Chung; Erasmo Simao da Silva

doi:10.1016/j.avsg.2020.08.111

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Experimental Study of Rupture Pressure and Elasticity of Abdominal Aortic Aneurysms Found at Autopsy

Journal article

Peer reviewed

Experimental Study of Rupture Pressure and Elasticity of Abdominal Aortic Aneurysms Found at Autopsy

Vivian Carla Gomes, Madhavan Lakshmi Raghavan, Luiz Fernando Ferraz da Silva, Jorge Gomes, Gina Camillo Silvestre, Alexandre Queiroz, Michele Alberto Marques, Selene Perrotti Zyngier, Timothy Kwang-Joon Chung and Erasmo Simao da Silva

Annals of vascular surgery, Vol.70, pp.517-527

01/2021

DOI: 10.1016/j.avsg.2020.08.111

PMID: 32891747

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Abstract

Resistance and elasticity of normal and aneurysmal aorta walls are directly associated with this vessel's growth and rupture. This study aims to experimentally analyze the biomechanical behavior of aneurysmal specimens found at autopsy, comparing them with normal diameter aortas removed from age-matched donors. Thirty-eight human aortas (30 normal aortas; 8 infrarenal abdominal aortic aneurysms) were harvested during autopsy. An apparatus was built with a digital gauge, plastic tray, connections, and hoses that conducted fluid (air) from a pump through the system. Specimens were dissected, and a flexible balloon was introduced in each of them to avoid leakage. The specimens were fastened on the test tray, and activation of the air pump enhanced system pressure up to their rupture. All 8 aneurysms and all 30 normal aortas specimens evolved to rupture under inflation pressures above 590 mm Hg (mean ± standard deviation = 1,035 ± 375 mm Hg) and 840 mm Hg (mean ± SD = 1,405 ± 342 mm Hg), respectively. In the aneurysm group, 25% of specimens did not rupture in their most dilated region. Percentage of increment in diameter was higher in normal aortas (mean ± SD = 0.2106 ± 0.144) than in aneurysms (mean ± SD = 0.093 ± 0.070). In the present experiment, unruptured infrarenal abdominal aortic aneurysms could support high pressures nearly as much as nonaneurysmal abdominal aortas. In some specimens, the most dilated part of the aneurysm was not the most vulnerable under pressure. Normal aortas presented higher elasticity than aneurysms.

Elasticity

Adult

Aged

Aged, 80 and over

Aorta, Abdominal - pathology

Aorta, Abdominal - physiopathology

Aortic Aneurysm, Abdominal - complications

Aortic Aneurysm, Abdominal - pathology

Aortic Aneurysm, Abdominal - physiopathology

Aortic Rupture - etiology

Aortic Rupture - pathology

Aortic Rupture - physiopathology

Arterial Pressure

Autopsy

Case-Control Studies

Dilatation, Pathologic

Female

Humans

Male

Middle Aged

Details

Title: Subtitle: Experimental Study of Rupture Pressure and Elasticity of Abdominal Aortic Aneurysms Found at Autopsy
Creators: Vivian Carla Gomes - Universidade de São Paulo
Madhavan Lakshmi Raghavan - University of Iowa
Luiz Fernando Ferraz da Silva - Universidade de São Paulo
Jorge Gomes - Shamah Engineering - Project Division - Av. Fagundes Filho, 361, room 11, São Paulo, São Paulo, Brazil.
Gina Camillo Silvestre - Universidade de São Paulo
Alexandre Queiroz - Universidade de São Paulo
Michele Alberto Marques - Universidade de São Paulo
Selene Perrotti Zyngier - Universidade de São Paulo
Timothy Kwang-Joon Chung - University of Iowa
Erasmo Simao da Silva - Universidade de São Paulo
Resource Type: Journal article
Publication Details: Annals of vascular surgery, Vol.70, pp.517-527
DOI: 10.1016/j.avsg.2020.08.111
PMID: 32891747
NLM abbreviation: Ann Vasc Surg
ISSN: 0890-5096
eISSN: 1615-5947
Language: English
Date published: 01/2021
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984197154202771

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