Journal article
Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)
Bone Reports, Vol.26, 101861
09/2025
DOI: 10.1016/j.bonr.2025.101861
PMCID: PMC12363472
PMID: 40837072
Abstract
Bone marrow adipose tissue (BMAT) is physiologically linked to bone and energy metabolism, endocrine regulation, hematopoiesis and cancer-related processes. A key challenge in the field is that methods for isolating BMAT or bone marrow adipocytes (BMAds) are variable because there are no widely adopted standardized protocols. To generate awareness of this challenge and to establish uniformity in experimental approaches requiring isolation, storage and characterization of BMAT and BMAds, the Biobanking Working Group of the international Bone Marrow Adiposity Society (BMAS) has previously recommended experimental standards. This paper provides an update on this effort and presents current state-of-the-art methods and technical considerations for isolation and characterization of BMAT and BMAds, including currently available high-throughput omics approaches. This review provides a reference point based on the consensus view of BMAS investigators to support studies on biomedical, biological, biochemical and biophysical questions associated with bone marrow adiposity.
•Bone marrow adipose tissue (BMAT) is critical for energy metabolism•BMAT supports bone homeostasis, endocrine regulation and hematopoiesis•BMAT and bone marrow adipocytes are dynamic and diverse across bone sites and species•Standardization, rigor and transparency is required to harmonize studies on BMAS•This review provides a consensus view for standards and technical considerations
Details
- Title: Subtitle
- Experimental analysis of bone marrow adipose tissue and bone marrow adipocytes: An update from the bone marrow adiposity society (BMAS)
- Creators
- Michaela Tencerova - Czech Academy of Sciences, Institute of PhysiologyBiagio Palmisano - Sapienza University of RomeStéphanie Lucas - Adiposité Médullaire et OsCamille Attané - Institut de Pharmacologie et de Biologie StructuraleKaisa K. Ivaska - University of TurkuLéa Loisay - University Hospital of LausanneYoshiko M. Ikushima - Tohoku UniversityDrenka Trivanovic - University of BelgradeAlessandro Corsi - Sapienza University of RomeAdriana Roque - Clinical Hematology Department, Centro Hospitalar e Universitário de Coimbra (CHUC), Coimbra, PortugalHongshuai Li - Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, United StatesFriederike Behler-Janbeck - University Medical Center Hamburg-EppendorfJeroen Geurts - University Hospital of LausanneMara Riminucci - Sapienza University of RomeIzabela Podgorski - Wayne State UniversityWilliam P. Cawthorn - University of EdinburghBram C.J. van der Eerden - Erasmus MCAndré J. van Wijnen - University of Vermont
- Resource Type
- Journal article
- Publication Details
- Bone Reports, Vol.26, 101861
- DOI
- 10.1016/j.bonr.2025.101861
- PMID
- 40837072
- PMCID
- PMC12363472
- NLM abbreviation
- Bone Rep
- ISSN
- 2352-1872
- eISSN
- 2352-1872
- Publisher
- Elsevier Inc
- Grant note
- National Institutes of Health: R01-AR076357, R01-AR083398, R01-CA251394, R01-049069
US based investigators that participated in the study were supported in part by funding from the National Institutes of Health through the following awards: R01-AR076357 and R01-AR083398 (HL) , R01-CA251394 (IP) and R01-049069 (AJvW) .
- Language
- English
- Electronic publication date
- 07/28/2025
- Date published
- 09/2025
- Academic Unit
- Orthopedics and Rehabilitation; Radiation Oncology
- Record Identifier
- 9984944720502771
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