Journal article
Experimental human exposure to inhaled grain dust and ammonia: towards a model of concentrated animal feeding operations
American journal of industrial medicine, Vol.46(4), pp.345-348
10/2004
DOI: 10.1002/ajim.20055
PMID: 15376225
Abstract
Ammonia and endotoxin-rich dust are present in high concentrations in swine confinement facilities; exposure to this environment is linked to workers' respiratory problems. We hypothesized that experimental exposure to ammonia and dust would impair pulmonary function, and that these exposures would be synergistic.
We exposed six normal subjects and eight subjects with mild asthma to ammonia (16-25 ppm) and/or endotoxin-rich grain dust (4 mg/m3). Pulmonary function and exhaled NOx were measured before and after exposure.
There was no significant change in pulmonary function in the normal subjects following any of the exposure conditions. Among asthmatics, a significant transient decrease in FEV1 was induced by grain dust, but was not altered by ammonia; increased bronchial hyperreactivity was also noted in this group.
In a vulnerable population, exposure to grain dust results in transient airflow obstruction. Short-term exposure to ammonia does not increase this response.
Details
- Title: Subtitle
- Experimental human exposure to inhaled grain dust and ammonia: towards a model of concentrated animal feeding operations
- Creators
- Sigurdur T Sigurdarson - Division of Pulmonary, Critical Care, and Occupational Medicine, Roy J. and Lucille A Carver College of Medicine, University of Iowa, Iowa City 52242, USAPatrick T O'ShaughnessyJanet A WattJoel N Kline
- Resource Type
- Journal article
- Publication Details
- American journal of industrial medicine, Vol.46(4), pp.345-348
- DOI
- 10.1002/ajim.20055
- PMID
- 15376225
- ISSN
- 0271-3586
- eISSN
- 1097-0274
- Grant note
- ES09607 / NIEHS NIH HHS HL59324 / NHLBI NIH HHS ES05605 / NIEHS NIH HHS RR00059 / NCRR NIH HHS
- Language
- English
- Date published
- 10/2004
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Civil and Environmental Engineering; Occupational and Environmental Health; Internal Medicine
- Record Identifier
- 9984094741202771
Metrics
14 Record Views