Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos

Pamela J Lein; Matthew R Bonner; Fayssal M Farahat; James R Olson; Diane S Rohlman; Richard A Fenske; K. Matthew Lattal; Michael R Lasarev; Kit Galvin; Taghreed M Farahat; W. Kent Anger

doi:10.1016/j.neuro.2011.12.017

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Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos

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Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos

Pamela J Lein, Matthew R Bonner, Fayssal M Farahat, James R Olson, Diane S Rohlman, Richard A Fenske, K. Matthew Lattal, Michael R Lasarev, Kit Galvin, Taghreed M Farahat, …

Neurotoxicology (Park Forest South), Vol.33(4), pp.660-668

08/2012

DOI: 10.1016/j.neuro.2011.12.017

PMCID: PMC3332151

PMID: 22240005

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Abstract

Translational research is needed to understand and predict the neurotoxic consequences associated with repeated occupational exposures to organophosphorus pesticides (OPs). In this report, we describe a research strategy for identifying biomarkers of OP neurotoxicity, and we characterize pesticide application workers in Egypt's Menoufia Governorate who serve as our anchor human population for developing a parallel animal model with similar exposures and behavioral deficits and for examining the influence of human polymorphisms in cytochrome P450 (CYP) and paraoxonase 1 (PON1) enzymes on OP metabolism and toxicity. This population has previously been shown to have high occupational exposures and to exhibit a broad range of neurobehavioral deficits. In addition to observational studies of work practices in the field, questionnaires on demographics, lifestyle and work practices were administered to 146 Egyptian pesticide application workers applying pesticides to the cotton crop. Survey results indicated that the application workforce uses standard operating procedures and standardized equipment provided by Egypt's Ministry of Agriculture, which provides a workforce with a stable work history. We also found that few workers report using personal protective equipment (PPE), which likely contributes to the relatively high exposures reported in these application workers. In summary, this population provides a unique opportunity for identifying biomarkers of OP-induced neurotoxicity associated with occupational exposure.

Chlorpyrifos

Biomarkers

Neurotoxicity

Organophosphorus pesticides

Occupational exposure

Details

Title: Subtitle: Experimental strategy for translational studies of organophosphorus pesticide neurotoxicity based on real-world occupational exposures to chlorpyrifos
Creators: Pamela J Lein - Department of Molecular Biosciences, UC Davis School of Veterinary Medicine, One Shields Ave, Davis, CA 95618, USA
Matthew R Bonner - Department of Social and Preventive Medicine, State University of New York at Buffalo, 143 Cary Hall, Buffalo, NY 14214, USA
Fayssal M Farahat - Department of Community Medicine and Public Health, Faculty of Medicine, Menoufia University, Gamel Abdel Nasser St., Shebin El-Kom, Egypt
James R Olson - Department of Social and Preventive Medicine, State University of New York at Buffalo, 143 Cary Hall, Buffalo, NY 14214, USA
Diane S Rohlman - Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University (OHSU), 3181 SW Sam Jackson Pk Rd L606, Portland, OR 97239, USA
Richard A Fenske - Department of Environmental and Occupational Health Sciences, Box 357234, University of Washington, Seattle, WA 98195, USA
K. Matthew Lattal - Department of Behavioral Neuroscience, OHSU, 3181 SW Sam Jackson Pk Rd L470, Portland, OR 97239, USA
Michael R Lasarev - Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University (OHSU), 3181 SW Sam Jackson Pk Rd L606, Portland, OR 97239, USA
Kit Galvin - Department of Environmental and Occupational Health Sciences, Box 357234, University of Washington, Seattle, WA 98195, USA
Taghreed M Farahat - Family Medicine Department, Faculty of Medicine, Menoufia University, Gamel Abdel Nasser St., Shebin El-Kom, Egypt
W. Kent Anger - Center for Research on Occupational and Environmental Toxicology (CROET), Oregon Health & Science University (OHSU), 3181 SW Sam Jackson Pk Rd L606, Portland, OR 97239, USA
Resource Type: Journal article
Publication Details: Neurotoxicology (Park Forest South), Vol.33(4), pp.660-668
DOI: 10.1016/j.neuro.2011.12.017
PMID: 22240005
PMCID: PMC3332151
NLM abbreviation: Neurotoxicology
ISSN: 0161-813X
eISSN: 1872-9711
Publisher: Elsevier B.V
Language: English
Date published: 08/2012
Academic Unit: Occupational and Environmental Health; International Programs; Injury Prevention Research Center
Record Identifier: 9983997486302771

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