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Expert Consensus Practice Recommendations of the North American Neuroendocrine Tumor Society for the management of high grade gastroenteropancreatic and gynecologic neuroendocrine neoplasms
Journal article   Open access   Peer reviewed

Expert Consensus Practice Recommendations of the North American Neuroendocrine Tumor Society for the management of high grade gastroenteropancreatic and gynecologic neuroendocrine neoplasms

Jennifer R Eads, Thorvardur R Halfdanarson, Tim Asmis, Andrew M. Bellizzi, Emily K Bergsland, Arvind Dasari, Ghassan El-Haddad, Michael Frumovittz, Joshua Meyer, Erik Mittra, …
Endocrine-related cancer, Vol.30(8), e220206
08/2023
DOI: 10.1530/ERC-22-0206
PMCID: PMC10388681
PMID: 37184955
url
https://doi.org/10.1530/ERC-22-0206View
Published (Version of record) Open Access

Abstract

High grade neuroendocrine tumors (G3 NET) and neuroendocrine carcinomas (NEC) are a rare disease entity for which there is a limited amount of prospective data available. It has also been relatively recent that a distinction has been made between G3 NET and NEC, further complicating the approach for management. Due to the overall lack of data in this space, much of the practice for treatment of these tumors is based on expect opinion. The North American Neuroendocrine Tumor Society (NANETS) is an organization composed of experts who specialize in the management of these tumors. In an effort to provide further guidance to the oncology community in regard to the management of these rare tumors, NANETS convened a panel of experts from medical oncology, surgery, interventional radiology, nuclear medicine, radiology, pathology and radiation oncology to address critical issues surrounding the management of G3 NET and NEC that would benefit from expert consensus opinion. Here we present the recommendations from this panel of neuroendocrine experts in regard to the management of high grade, extra-pulmonary neuroendocrine tumors (G3 NET) and neuroendocrine carcinomas (NEC).

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