Journal article
Exploring craniofacial and dental development with microRNAs
Biochemical Society Transactions, Vol.50(6), pp.1897-1909
12/2022
DOI: 10.1042/BST20221042
PMID: 36484693
Abstract
microRNAs (miRs) are small RNA molecules that regulate many cellular and developmental processes. They control gene expression pathways during specific developmental time points and are required for tissue homeostasis and stem cell maintenance. miRs as therapeutic reagents in tissue regeneration and repair hold great promise and new technologies are currently being designed to facilitate their expression or inhibition. Due to the large amount of miR research in cells and cancer many cellular processes and gene networks have been delineated however, their in vivo response can be different in complex tissues and organs. Specifically, this report will discuss animal developmental models to understand the role of miRs as well as xenograft, disease, and injury models. We will discuss the role of miRs in clinical studies including their diagnostic function, as well as their potential ability to correct craniofacial diseases.
Details
- Title: Subtitle
- Exploring craniofacial and dental development with microRNAs
- Creators
- Dan Su - University of IowaTadkamol Krongbaramee - Chiang Mai UniversityHongli Sun - University of IowaLiu Hong - University of IowaBrad A Amendt - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biochemical Society Transactions, Vol.50(6), pp.1897-1909
- DOI
- 10.1042/BST20221042
- PMID
- 36484693
- NLM abbreviation
- Biochem Soc Trans
- ISSN
- 0300-5127
- eISSN
- 1470-8752
- Language
- English
- Date published
- 12/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthodontics; Anatomy and Cell Biology; Prosthodontics; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery; Dental Research
- Record Identifier
- 9984322741702771
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