Exploring microRNAs in craniofacial regenerative medicine

Dan Su; Samuel Swearson; Tadkamol Krongbaramee; Hongli Sun; Liu Hong; Brad A Amendt

doi:10.1042/BST20221448

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Exploring microRNAs in craniofacial regenerative medicine

Journal article

Peer reviewed

Exploring microRNAs in craniofacial regenerative medicine

Dan Su, Samuel Swearson, Tadkamol Krongbaramee, Hongli Sun, Liu Hong and Brad A Amendt

Biochemical Society transactions, Vol.51(2), pp.841-854

04/2023

DOI: 10.1042/BST20221448

PMCID: PMC11244734

PMID: 37073783

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https://pmc.ncbi.nlm.nih.gov/articles/PMC11244734/pdf/nihms-2006088.pdfView

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Abstract

microRNAs (miRs) have been reported over the decades as important regulators in bone development and bone regeneration. They play important roles in maintaining the stem cell signature as well as regulating stem cell fate decisions. Thus, delivering miRs and miR inhibitors to the defect site is a potential treatment towards craniofacial bone defects. However, there are challenges in translation of basic research to clinics, including the efficiency, specificity, and efficacy of miR manipulation methods and the safety of miR delivery systems. In this review, we will compare miR oligonucleotides, mimics and antagomirs as therapeutic reagents to treat disease and regenerate tissues. Newer technology will be discussed as well as the efficiency and efficacy of using these technologies to express or inhibit miRs in treating and repairing oral tissues. Delivery of these molecules using extracellular vesicles and nanoparticles can achieve different results and depending on their composition will elicit specific effects. We will highlight the specificity, toxicity, stability, and effectiveness of several miR systems in regenerative medicine.

tissue regeneration

PMIS

bone formation

microRNA therapeutics

plasmid-based microRNA inhibitor system

tissue repair

Details

Title: Subtitle: Exploring microRNAs in craniofacial regenerative medicine
Creators: Dan Su - University of Iowa
Samuel Swearson - University of Iowa
Tadkamol Krongbaramee - University of Iowa
Hongli Sun - University of Iowa
Liu Hong - University of Iowa
Brad A Amendt - University of Iowa
Resource Type: Journal article
Publication Details: Biochemical Society transactions, Vol.51(2), pp.841-854
DOI: 10.1042/BST20221448
PMID: 37073783
PMCID: PMC11244734
NLM abbreviation: Biochem Soc Trans
eISSN: 1470-8752
Language: English
Electronic publication date: 04/19/2023
Date published: 04/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Orthodontics; Anatomy and Cell Biology; Prosthodontics; Craniofacial Anomalies Research Center; Oral and Maxillofacial Surgery; Dental Research
Record Identifier: 9984398211102771

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