Journal article
Exploring sex-specific clinical features in Chinese patients with Takotsubo syndrome
BMC cardiovascular disorders, Vol.25(1), p.490
07/05/2025
DOI: 10.1186/s12872-025-04788-4
PMCID: PMC12229039
PMID: 40618029
Abstract
Takotsubo syndrome (TTS) is considered as a transient acute heart failure syndrome predominant in females. However, data on Chinese TTS patients are limited. Therefore, this study aimed to investigate the clinical characteristics of Chinese TTS patients, identify prognostic markers.BACKGROUNDTakotsubo syndrome (TTS) is considered as a transient acute heart failure syndrome predominant in females. However, data on Chinese TTS patients are limited. Therefore, this study aimed to investigate the clinical characteristics of Chinese TTS patients, identify prognostic markers.A total of 258 TTS patients were enrolled. Data on clinical characteristics and in-hospital major adverse cardiovascular events (MACE) were collected and analyzed. The latter included severe heart failure, shock, malignant arrhythmia, and death.METHODSA total of 258 TTS patients were enrolled. Data on clinical characteristics and in-hospital major adverse cardiovascular events (MACE) were collected and analyzed. The latter included severe heart failure, shock, malignant arrhythmia, and death.The average age of TTS patients was 59.3 ± 19.2 years. Female patients accounted for 68.9%. MACE occurred in 41.4% of patients during hospitalization. Compared with males, female TTS patients were older, had more emotional causes, higher proportion of typical apical ballooning type, higher LVEF, more prolonged QTc, as well as lower early repolarization (ER) and MACE ratio (35.6% vs. 53.8%, P = 0.006). Compared to female patients with emotional triggers, those female patients with physical triggers are younger, have a lower proportion of chest pain and abnormal ECG, but are more prone to experiencing MACE. Physical triggers, CKMB, LVEF, non-apical ballooning, ER pattern and premature ventricular beats were independent predictors of in-hospital MACE, whereas age, physical triggers and platelet count were specifically independent predictors for female TTS cases.RESULTSThe average age of TTS patients was 59.3 ± 19.2 years. Female patients accounted for 68.9%. MACE occurred in 41.4% of patients during hospitalization. Compared with males, female TTS patients were older, had more emotional causes, higher proportion of typical apical ballooning type, higher LVEF, more prolonged QTc, as well as lower early repolarization (ER) and MACE ratio (35.6% vs. 53.8%, P = 0.006). Compared to female patients with emotional triggers, those female patients with physical triggers are younger, have a lower proportion of chest pain and abnormal ECG, but are more prone to experiencing MACE. Physical triggers, CKMB, LVEF, non-apical ballooning, ER pattern and premature ventricular beats were independent predictors of in-hospital MACE, whereas age, physical triggers and platelet count were specifically independent predictors for female TTS cases.Chinese TTS patients demonstrate unique clinical characteristics and in-hospital outcomes. Apart from the well-known fact that male with TTS has high-risk phenotype, our study newly identifies that TTS females with younger age or physical triggers also have worse prognosis, which warrants close attention and follow-up.CONCLUSIONSChinese TTS patients demonstrate unique clinical characteristics and in-hospital outcomes. Apart from the well-known fact that male with TTS has high-risk phenotype, our study newly identifies that TTS females with younger age or physical triggers also have worse prognosis, which warrants close attention and follow-up.
Details
- Title: Subtitle
- Exploring sex-specific clinical features in Chinese patients with Takotsubo syndrome
- Creators
- Hong-Yi Duan - Wuhan UniversityLing-Lin WangLing-Chun LyuZhen-Hua ShiXiao-Ping LinZheng-Yang YuGuo-Hua FanJing Chen - Wuhan UniversityXin-Hong YangWei Deng - Wuhan UniversityChang-Wu XuYan Huang - Wuhan UniversityQing Zhou - Renmin Hospital of Wuhan UniversityJin-Ling ChenHong-Ning SongDong Hu - Union HospitalJin-Qiu LiuHector Barajas-Martinez - Lankenau Institute for Medical ResearchCharles Antzelevitch - Lankenau Institute for Medical ResearchKan Liu - Washington University in St. LouisHong Jiang - Wuhan UniversityDan Hu - Renmin Hospital of Wuhan University
- Resource Type
- Journal article
- Publication Details
- BMC cardiovascular disorders, Vol.25(1), p.490
- DOI
- 10.1186/s12872-025-04788-4
- PMID
- 40618029
- PMCID
- PMC12229039
- NLM abbreviation
- BMC Cardiovasc Disord
- ISSN
- 1471-2261
- eISSN
- 1471-2261
- Publisher
- BMC
- Grant note
- National Key Research and Development Program of China
We appreciate the technical support from Bo Chen at Renmin Hospital of Wuhan University.
- Language
- English
- Date published
- 07/05/2025
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984843590402771
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