Journal article
Exploring the Effects of C-Reactive Protein (CRP) and Interleukin-1 β Single Nucleotide Polymorphisms on CRP Concentration in Patients With Established Coronary Artery Disease: A Classification Tree Approach
International heart journal, Vol.48(4), pp.463-475
2007
DOI: 10.1536/ihj.48.463
PMID: 17827818
Abstract
Purpose: This study was designed to illustrate the effects of C-reactive protein (CRP) and interleukin polymorphisms on serum CRP levels.
Methods: A total of 390 patients with coronary heart disease (CHD) were recruited and high-sensitivity CRP levels were measured. Six polymorphic alleles on the genes of CRP, IL-1, and the IL-1 receptor antagonist were identified. A classification tree was applied to determine their effects and interactions on serum CRP levels.
Results: In the hypertensive CHD patients, the presence of CRP + 1059 GC heterozygotes was associated with a lower risk for elevated CRP levels (OR = 0.318, P = 0.001). The coexistence of CRP + 1059 GC and IL-1β-511 (CT or TT) might result in reduction in the CRP levels compared to IL-1β-511 CC (OR = 0.222, P = 0.088 and OR = 0.148, P = 0.060, respectively).
Conclusion: The results demonstrated the distribution of CRP-related polymorphisms and the interactions in Taiwanese patients with CHD.
Details
- Title: Subtitle
- Exploring the Effects of C-Reactive Protein (CRP) and Interleukin-1 β Single Nucleotide Polymorphisms on CRP Concentration in Patients With Established Coronary Artery Disease: A Classification Tree Approach
- Creators
- Jou-Wei Lin - Cardiovascular Center, National Taiwan University Hospital, Yun-Lin Branch, Institute of Electrical Engineering, National Chung-Cheng UniversityDao-Fu Dai - Section of Cardiology, Department of Internal Medicine, National Taiwan University HospitalYi-Hua Chou - Section of Cardiology, Department of Internal Medicine, National Taiwan University HospitalLi-Ying Huang - Section of Cardiology, Department of Internal Medicine, National Taiwan University HospitalJuey-Jen Hwang - Cardiovascular Center, National Taiwan University Hospital, Yun-Lin Branch, Section of Cardiology, Department of Internal Medicine, National Taiwan University Hospital
- Resource Type
- Journal article
- Publication Details
- International heart journal, Vol.48(4), pp.463-475
- DOI
- 10.1536/ihj.48.463
- PMID
- 17827818
- ISSN
- 1349-2365
- eISSN
- 1349-3299
- Language
- English
- Date published
- 2007
- Academic Unit
- Pathology; Iowa Neuroscience Institute; Radiation Oncology
- Record Identifier
- 9984046922402771
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