Journal article
Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review
Frontiers in public health, Vol.12, 1383851
10/16/2024
DOI: 10.3389/fpubh.2024.1383851
PMCID: PMC11521889
PMID: 39478741
Abstract
Asthma is a highly prevalent inflammatory condition, significantly affecting nearly six million U.S. children and impacting various facets of their developmental trajectories including neurodevelopment. Evidence supports a link between pediatric environmental exposures in two key areas: asthma and executive function (E.F.). E.F.s are a collective of higher-order cognitive processes facilitating goal-oriented behaviors. Studies also identify asthma-associated E.F. impairments in children. However, limited research has evaluated the inter-relationships among environmental exposures, asthma, and E.F. in children. This review explored relevant research to identify and connect the potential mechanisms and pathways underlying these dynamic associations. The review suggests that the role of the pediatric exposome may function through (1) several underlying biological pathways (i.e., the lung-brain axis, neuroendocrine system, and hypoxia), which could drive asthma and maladaptive E.F. in children and (2) the relationships between the exposome, asthma, and E.F. is a bidirectional linkage. The review reveals essential synergistic links between asthma and E.F. deficits, highlighting the potential role of the pediatric exposome.
Details
- Title: Subtitle
- Exploring the link between the pediatric exposome, respiratory health, and executive function in children: a narrative review
- Creators
- Cecilia S. AlcalaJamil M. LaneVishal MidyaShoshannah EggersRobert O. WrightMaria José Rosa
- Resource Type
- Journal article
- Publication Details
- Frontiers in public health, Vol.12, 1383851
- DOI
- 10.3389/fpubh.2024.1383851
- PMID
- 39478741
- PMCID
- PMC11521889
- NLM abbreviation
- Front Public Health
- ISSN
- 2296-2565
- eISSN
- 2296-2565
- Publisher
- FRONTIERS MEDIA SA
- Grant note
- National Institute of Child Health and Human Development: T32HD049311 National Institute of Environmental Health Sciences: R00ES027496, R01ES033245, R01ES014930, R01ES013744, R24ES028522, P30ES023515, R01ES026033, R01MH122447, R01ES029511, R01ES028927
The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the by the National Institute of Child Health and Human Development grant T32HD049311 (Alcala, CS; Lane, JM). The National Institute of Environmental Health Sciences grant, R00ES027496 and R01ES033245 (Rosa MJ, PI); and R01ES014930, R01ES013744, R24ES028522, P30ES023515, R01ES026033, R01MH122447, R01ES029511, and R01ES028927 (Wright, RO, PI).
- Language
- English
- Date published
- 10/16/2024
- Academic Unit
- Epidemiology; Injury Prevention Research Center
- Record Identifier
- 9984729504202771
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