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Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze
Journal article   Open access   Peer reviewed

Exposure and Sensitization to Pets Modify Endotoxin Association with Asthma and Wheeze

Angelico Mendy, Jesse Wilkerson, Päivi M Salo, Richard D Cohn, Darryl C Zeldin and Peter S Thorne
The journal of allergy and clinical immunology in practice (Cambridge, MA), Vol.6(6), pp.2006-2013.e4
11/2018
DOI: 10.1016/j.jaip.2018.04.009
PMCID: PMC6524530
PMID: 29684578
url
https://www.ncbi.nlm.nih.gov/pmc/articles/6524530View
Open Access

Abstract

Pets are major contributors of endotoxin in homes, but whether they influence endotoxin association with respiratory outcomes is unclear. To examine whether exposure and sensitization to dog and cat modify the relationship between endotoxin exposure and asthma and wheeze. We analyzed data from 6051 participants in the 2005-2006 cycle of the National Health and Nutrition Examination Survey (NHANES). House dust from bedroom floor and bedding was evaluated for endotoxin and for dog (Canis familiaris 1) and cat (Feline domesticus 1) allergens. The NHANES also collected data on respiratory outcomes and measured IgE specific to allergens. Associations of log-endotoxin and pet exposure with respiratory outcomes were examined, adjusting for covariates including pet avoidance. Dog and cat ownership among participants was 48.3% and 37.5%, respectively. Endotoxin geometric mean (SE) was 15.49 (0.50) EU/mg. Endotoxin and pet allergen levels were significantly higher in households with a dog or cat. Overall, endotoxin was positively associated with wheeze (odds ratio [OR], 1.30; 95% CI, 1.04-1.62), but not with asthma. However, in participants nonsensitized to dog, the odds of endotoxin association with wheeze were higher with exposure to dog allergen (OR, 1.80; 95% CI, 1.27-2.53; Pinteraction = .048). In participants sensitized to cat and exposed to cat allergen, endotoxin became positively associated with asthma (OR, 1.92; 95% CI, 1.21-3.0; Pinteraction = .040). With coexposure to dog and cat allergens, endotoxin association with asthma and wheeze was exacerbated (OR, 2.00; 95% CI, 1.04-3.83; Pinteraction = .012 and OR, 1.88; 95% CI, 1.32-2.66; Pinteraction = .016, respectively). Exposure to dog and cat allergens enhances the association of endotoxin with asthma and wheeze.
 Pets Wheeze Sensitization Endotoxin House dust Asthma

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