Journal article
Exposure to PCB52 (2,2',5,5'-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose
Environmental toxicology and pharmacology, Vol.113, 104612
01/2025
DOI: 10.1016/j.etap.2024.104612
PMCID: PMC11717591
PMID: 39674530
Abstract
Polychlorinated biphenyls (PCBs) are linked to cancer, learning disabilities, liver and cardiovascular disease, and diabetes. Older schools often contain high levels of PCBs, and inhalation is a major source of exposure. Technical PCB mixtures, called Aroclors, and individual dioxin-like PCBs impair adipocyte function, which can lead to type II diabetes. To determine how PCB52, a non-dioxin like PCB congener found in school air, affects adipose, adolescent male and female rats were exposed to PCB52 by nose-only inhibition for 4h per day for 28 consecutive days. Transcriptomic analysis of white adipose revealed sex-specific differences in gene expression between PCB52- and sham-exposed males and females. Exposed females showed mitochondrial gene changes, including downregulation of the thermogenic uncoupling gene, Ucp1. Human preadipocytes/adipocytes exposed to PCB52 or its main metabolite, 4-OH-PCB52, also showed reduced norepinephrine-induced UCP1 expression. These findings suggest that PCB52 inhalation disrupts thermogenesis in adipose tissue, potentially contributing to metabolic syndrome.
Details
- Title: Subtitle
- Exposure to PCB52 (2,2',5,5'-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose
- Creators
- Francoise A Gourronc - Department of Microbiology and Immunology, Carver College of MedicineAmanda J Bullert - Interdisciplinary Graduate Program in NeuroscienceBrynn Kyleakin Helm-Kwasny - Molecular Medicine Graduate ProgramAndrea Adamcakova-Dodd - Department of Occupational and Environmental HealthHui Wang - University of Iowa, Occupational and Environmental HealthXuefang Jing - Department of Occupational and Environmental HealthXueshu Li - Department of Occupational and Environmental HealthPeter S Thorne - Department of Occupational and Environmental HealthHans-Joachim LehmlerJames A AnkrumAloysius J Klingelhutz
- Resource Type
- Journal article
- Publication Details
- Environmental toxicology and pharmacology, Vol.113, 104612
- DOI
- 10.1016/j.etap.2024.104612
- PMID
- 39674530
- PMCID
- PMC11717591
- NLM abbreviation
- Environ Toxicol Pharmacol
- ISSN
- 1382-6689
- eISSN
- 1872-7077
- Publisher
- ELSEVIER
- Grant note
- Iowa Superfund Research Program: NIH P42 ES013661
This research was supported by the Iowa Superfund Research Program (NIH P42 ES013661) . Inhalation exposures were carried out in the EHSRC Pulmonary Toxicology Facility (NIH P30 ES005605) . This content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies listed above.
- Language
- English
- Electronic publication date
- 12/12/2024
- Date published
- 01/2025
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Public Health Administration; Civil and Environmental Engineering; Microbiology and Immunology; Occupational and Environmental Health; Iowa Neuroscience Institute; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Iowa Superfund Research Program
- Record Identifier
- 9984757687102771
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