Journal article
Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes
Cell metabolism, Vol.32(4), pp.561-574.e7
10/06/2020
DOI: 10.1016/j.cmet.2020.09.012
PMID: 33027675
Abstract
Aberrant redox signaling underlies the pathophysiology of many chronic metabolic diseases, including type 2 diabetes (T2D). Methodologies aimed at rebalancing systemic redox homeostasis have had limited success. A noninvasive, sustained approach would enable the long-term control of redox signaling for the treatment of T2D. We report that static magnetic and electric fields (sBE) noninvasively modulate the systemic GSH-to-GSSG redox couple to promote a healthier systemic redox environment that is reducing. Strikingly, when applied to mouse models of T2D, sBE rapidly ameliorates insulin resistance and glucose intolerance in as few as 3 days with no observed adverse effects. Scavenging paramagnetic byproducts of oxygen metabolism with SOD2 in hepatic mitochondria fully abolishes these insulin sensitizing effects, demonstrating that mitochondrial superoxide mediates induction of these therapeutic changes. Our findings introduce a remarkable redox-modulating phenomenon that exploits endogenous electromagneto-receptive mechanisms for the noninvasive treatment of T2D, and potentially other redox-related diseases.
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•Combined static magnetic and electric fields (sBE) enhance insulin sensitivity•sBE is not associated with adverse effects•sBE triggers a systemic redox response to modulate insulin sensitivity•Scavenging mitochondrial superoxide in the liver abolishes the effects of sBE
Abnormal redox homeostasis contributes to the pathogenesis of type 2 diabetes. However, targeting redox systems remains a challenge. In this issue, Carter, Huang et al. demonstrate that static magnetic and electric fields can be used to modulate redox systems for the noninvasive treatment of type 2 diabetes.
Details
- Title: Subtitle
- Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes
- Creators
- Calvin S Carter - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USASunny C Huang - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USACharles C Searby - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USABenjamin Cassaidy - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USAMichael J Miller - Department of Physics and Astronomy, University of Iowa, Iowa City, IA, USAWojciech J Grzesik - Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USATed B Piorczynski - Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USAThomas K Pak - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USASusan A Walsh - Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USAMichael Acevedo - Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USAQihong Zhang - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USAKranti A Mapuskar - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USAGinger L Milne - Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USAAntentor O Hinton - Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USADeng-Fu Guo - Department of Neuroscience and Pharmacology, University of Iowa Hospitals & Clinics, Iowa City, IA, USARobert Weiss - Department of Internal Medicine, Division of Cardiology, University of Iowa Hospitals & Clinics, Iowa City, IA, USAKyle Bradberry - Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USAEric B Taylor - Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USAAdam J Rauckhorst - Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USADavid W Dick - Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USAVamsidhar Akurathi - Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals & Clinics, Iowa City, IA, USAKelly C Falls-Hubert - Medical Scientist Training Program, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USABrett A Wagner - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USAWalter A Carter - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USAKai Wang - College of Public Health, Department of Biostatistics, University of Iowa, Iowa City, IA, USAAndrew W Norris - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USAKamal Rahmouni - Department of Neuroscience and Pharmacology, University of Iowa Hospitals & Clinics, Iowa City, IA, USAGarry R Buettner - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USAJason M Hansen - Department of Physiology and Developmental Biology, Brigham Young University, Provo, UT, USADouglas R Spitz - Free Radical and Radiation Biology Program, Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa Hospitals & Clinics, Iowa City, IA, USAE. Dale Abel - Fraternal Order of Eagles Diabetes Research Center, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA, USAVal C Sheffield - Department of Pediatrics and Division of Medical Genetics and Genomics, University of Iowa Hospitals & Clinics, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Cell metabolism, Vol.32(4), pp.561-574.e7
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.cmet.2020.09.012
- PMID
- 33027675
- ISSN
- 1550-4131
- eISSN
- 1932-7420
- Grant note
- DOI: 10.13039/100000041, name: American Diabetes Association
- Language
- English
- Date published
- 10/06/2020
- Academic Unit
- Endocrinology and Diabetes; Pathology; Pharmaceutical Sciences and Experimental Therapeutics; Biostatistics; Medical Genetics and Genomics; Biochemistry and Molecular Biology; Endocrinology and Metabolism; Roy J. Carver Department of Biomedical Engineering; Radiology; Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Cardiovascular Medicine; Physics and Astronomy; Radiation Oncology; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984070553502771
Metrics
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