Exposure to schistosome eggs protects mice from TNBS-induced colitis

David E Elliott; Jie Li; Arthur Blum; Ahmed Metwali; Khurram Qadir; Joseph F Urban Jr; Joel V Weinstock

doi:10.1152/ajpgi.00049.2002

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Exposure to schistosome eggs protects mice from TNBS-induced colitis

Journal article

Peer reviewed

Exposure to schistosome eggs protects mice from TNBS-induced colitis

David E Elliott, Jie Li, Arthur Blum, Ahmed Metwali, Khurram Qadir, Joseph F Urban Jr and Joel V Weinstock

American journal of physiology: Gastrointestinal and liver physiology, Vol.284(3), pp.G385-391

03/2003

DOI: 10.1152/ajpgi.00049.2002

PMID: 12431903

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Abstract

Crohn's disease results from dysregulated T helper (Th)1-type mucosal inflammation. Crohn's disease is rare in tropical countries but prevalent in developed countries with temperate climates, in which its incidence rose after 1940. In contrast, exposure to helminthic parasites is common in tropical countries but is rare in developed countries. Helminthic parasites induce immunomodulatory T cell responses in the host. We hypothesize that immunomodulatory responses due to helminths may attenuate excessive Th1-type inflammation. To test that hypothesis, mice were exposed to eggs of the helminth Schistosoma mansoni and then challenged rectally with trinitrobenzesulfonic acid (TNBS) to induce colitis. Schistosome egg exposure attenuated TNBS colitis and protected mice from lethal inflammation. Schistosome egg exposure diminished IFN-gamma and enhanced IL-4 production from alphaCD3-stimulated spleen and mesenteric lymph node cells of TNBS-treated mice. Schistosome egg exposure decreased colonic IFN-gamma but increased IL-10 mRNA expression in TNBS-treated mice. Intact signal transducer and activator of transcription 6 was required for attenuation of colitis. Exposure to helminths can decrease murine colonic inflammation.

Mesentery - metabolism

Schistosoma mansoni - physiology

Cytokines - metabolism

Enzyme-Linked Immunosorbent Assay

Hypoxanthine Phosphoribosyltransferase - metabolism

Lymph Nodes - metabolism

Colitis - pathology

Trinitrobenzenesulfonic Acid

Reverse Transcriptase Polymerase Chain Reaction

Animals

Spleen - metabolism

Colitis - chemically induced

Ovum - chemistry

Mice

Mice, Inbred BALB C

Colitis - prevention & control

Cytokines - biosynthesis

Intestinal Mucosa - pathology

Details

Title: Subtitle: Exposure to schistosome eggs protects mice from TNBS-induced colitis
Creators: David E Elliott - Department of Internal Medicine, Division of Gastroenterology-Hepatology, University of Iowa College of Medicine, Iowa City, IA 52242, USA. david-elliott@uiowa.edu
Jie Li
Arthur Blum
Ahmed Metwali
Khurram Qadir
Joseph F Urban Jr
Joel V Weinstock
Resource Type: Journal article
Publication Details: American journal of physiology: Gastrointestinal and liver physiology, Vol.284(3), pp.G385-391
DOI: 10.1152/ajpgi.00049.2002
PMID: 12431903
ISSN: 0193-1857
eISSN: 1522-1547
Grant note: DK 02428 / NIDDK NIH HHS DK 25295 / NIDDK NIH HHS DK 38327 / NIDDK NIH HHS DK 58755 / NIDDK NIH HHS
Language: English
Date published: 03/2003
Academic Unit: Gastroenterology and Hepatology; Internal Medicine
Record Identifier: 9984094374402771

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