Journal article
Expression and Function of FGF10 in Mammalian Inner Ear Development
Developmental dynamics, Vol.227(2), pp.203-215
06/2003
DOI: 10.1002/dvdy.10297
PMCID: PMC3904739
PMID: 12761848
Abstract
We have investigated the expression of FGF10 during ear development and the effect of an FGF10 null mutation on ear development. Our in situ hybridization data reveal expression of FGF10 in all three canal crista sensory epithelia and the cochlea anlage as well as all sensory neurons at embryonic day 11.5 (E11.5). Older embryos (E18.5) displayed strong graded expression in all sensory epithelia. FGF10 null mutants show complete agenesis of the posterior canal crista and the posterior canal. The posterior canal sensory neurons form initially and project rather normally by E11.5, but they disappear within 2 days. FGF10 null mutants have no posterior canal system at E18.5. In addition, these mutants have deformations of the anterior and horizontal cristae, reduced formation of the anterior and horizontal canals, as well as altered position of the remaining sensory epithelia with respect to the utricle. Hair cells form but some have defects in their cilia formation. No defects were detected in the organ of Corti at the cellular level. Together these data suggest that FGF10 plays a major role in ear morphogenesis. Most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of FGF10’s main receptors.
Details
- Title: Subtitle
- Expression and Function of FGF10 in Mammalian Inner Ear Development
- Creators
- Sarah Pauley - Creighton University, Department of Biomedical Sciences, Omaha, NebraskaTracy J Wright - University of Utah, Department of Human Genetics, Salt Lake City, UtahUlla Pirvola - Institute of Biotechnology, University of Helsinki, FinlandDavid Ornitz - Department of Molecular Biology, Washington University, St. Louis, MissouriKirk Beisel - Creighton University, Department of Biomedical Sciences, Omaha, NebraskaBernd Fritzsch - Creighton University, Department of Biomedical Sciences, Omaha, Nebraska
- Resource Type
- Journal article
- Publication Details
- Developmental dynamics, Vol.227(2), pp.203-215
- DOI
- 10.1002/dvdy.10297
- PMID
- 12761848
- PMCID
- PMC3904739
- NLM abbreviation
- Dev Dyn
- ISSN
- 1058-8388
- eISSN
- 1097-0177
- Grant note
- R01 DC005590-03 || DC / National Institute on Deafness and Other Communication Disorders : NIDCD
- Language
- English
- Date published
- 06/2003
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984070538602771
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