Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells

H Tamir; S C Hsiung; Kuo-Peing Liu; Randy D Blakely; A F Russo; M S Clark; Eladio A Nunez; M D Gershon

doi:10.1210/endo.137.10.8828510

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Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells

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Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells

H Tamir, S C Hsiung, Kuo-Peing Liu, Randy D Blakely, A F Russo, M S Clark, Eladio A Nunez and M D Gershon

Endocrinology (Philadelphia), Vol.137(10), pp.4475-4486

10/1996

DOI: 10.1210/endo.137.10.8828510

PMID: 8828510

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Abstract

5-Hydroxytryptamine (5-HT) is synthesized and secreted by thyroid parafollicular (PF) cells. As all PF granules contain 5-HT, it is released whenever PF cells secrete. Because 5-HT stimulates follicular (F) cells and can modulate their response to TSH, 5-HT has been proposed to be a paracrine PF to F cell transmitter. This role would require a thyroid mechanism to rapidly inactivate 5-HT. A 5-HT transporter (SERT) in the plasma membrane of serotonergic neurons inactivates neuronal 5-HT. We thus tested the hypothesis that this molecule is expressed in the thyroid. Messenger RNA encoding SERT was demonstrated in both the human thyroid and a rat F cell line (FRTL-5). SERT immunoreactivity was detected in rat F, but not PF, cells. Transporter-mediated uptake of [3H]5-HT by F cells arose early in development (E13 in mice) and was maintained in adult life in mice, guinea pigs, bats, and rats (FRTL-5 cells). These observations indicate that a functional SERT is expressed in the thyroid, not by the 5-HT-secreting PF cells, but by their putative F cell targets.

Details

Title: Subtitle: Expression and development of a functional plasmalemmal 5-hydroxytryptamine transporter by thyroid follicular cells
Creators: H Tamir
S C Hsiung
Kuo-Peing Liu
Randy D Blakely
A F Russo
M S Clark
Eladio A Nunez
M D Gershon
Resource Type: Journal article
Publication Details: Endocrinology (Philadelphia), Vol.137(10), pp.4475-4486
DOI: 10.1210/endo.137.10.8828510
PMID: 8828510
NLM abbreviation: Endocrinology
ISSN: 0013-7227
eISSN: 1945-7170
Language: English
Date published: 10/1996
Academic Unit: Neurology; Molecular Physiology and Biophysics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center
Record Identifier: 9984020650402771

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