Journal article
Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression
Cancer research (Chicago, Ill.), Vol.78(9), pp.2343-2355
05/01/2018
DOI: 10.1158/0008-5472.can-17-2465
PMCID: PMC5932212
PMID: 29437708
Abstract
Tumor-associated macrophages (TAM) play a critical role in cancer development and progression. However, the heterogeneity of TAM presents a major challenge to identify clinically relevant markers for protumor TAM. Here, we report that expression of adipocyte/macrophage fatty acid-binding protein (A-FABP) in TAM promotes breast cancer progression. Although upregulation of A-FABP was inversely associated with breast cancer survival, deficiency of A-FABP significantly reduced mammary tumor growth and metastasis. Furthermore, the protumor effect of A-FABP was mediated by TAM, in particular, in a subset of TAM with a CD11b
F4/80
MHCII
Ly6C
phenotype. A-FABP expression in TAM facilitated protumor IL6/STAT3 signaling through regulation of the NFκB/
pathway. Collectively, our results suggest A-FABP as a new functional marker for protumor TAM.
These findings identify A-FABP as a functional marker for protumor macrophages, thus offering a new target for tumor immunotherapy.
.
Details
- Title: Subtitle
- Expression of Adipocyte/Macrophage Fatty Acid-Binding Protein in Tumor-Associated Macrophages Promotes Breast Cancer Progression
- Creators
- Jiaqing Hao - University of LouisvilleFei Yan - University of MinnesotaYuwen Zhang - University of LouisvilleAshley Triplett - University of LouisvilleYing Zhang - University of MinnesotaDebra A Schultz - Mayo ClinicYanwen Sun - University of LouisvilleJun Zeng - University of LouisvilleKevin A T Silverstein - University of MinnesotaQi Zheng - University of LouisvilleDavid A Bernlohr - University of MinnesotaMargot P Cleary - University of MinnesotaNejat K Egilmez - University of LouisvilleEdward Sauter - Hartford Healthcare Cancer Institute, Hartford, ConnecticutShujun Liu - University of MinnesotaJill Suttles - University of LouisvilleBing Li - University of Louisville
- Resource Type
- Journal article
- Publication Details
- Cancer research (Chicago, Ill.), Vol.78(9), pp.2343-2355
- DOI
- 10.1158/0008-5472.can-17-2465
- PMID
- 29437708
- PMCID
- PMC5932212
- NLM abbreviation
- Cancer Res
- ISSN
- 0008-5472
- eISSN
- 1538-7445
- Grant note
- R56 AI048850 / NIAID NIH HHS R21 AI048850 / NIAID NIH HHS R01 CA180986 / NCI NIH HHS R01 CA177679 / NCI NIH HHS R01 DK053189 / NIDDK NIH HHS R01 AI048850 / NIAID NIH HHS
- Language
- English
- Date published
- 05/01/2018
- Academic Unit
- Pathology; Surgery
- Record Identifier
- 9984695792102771
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