Journal article
Expression of LEF1 in mantle cell lymphoma
Annals of diagnostic pathology, Vol.26, pp.57-59
02/2017
DOI: 10.1016/j.anndiagpath.2016.09.016
PMID: 28038713
Abstract
Small lymphocytic lymphoma/chronic lymphocytic leukemia (CLL/SLL) and mantle cell lymphoma (MCL) usually are distinctly different in regard to clinical presentation, morphology, immunophenotype and molecular/genetic findings. In spite of this, select cases may show overlapping characteristics and represent a diagnostic challenge. Recently LEF1 staining was identified as a fairly characteristic finding in CLL/SLL, with positivity identified in up to 95% of cases. LEF1 staining has not been reported as being present in cases of MCL, making this stain a useful tool in distinguishing these diagnoses. We identified an index case of MCL with cyclin D1 expression and the presence of the typical t(11;14) IGH-CCND1, which expressed LEF1. Subsequently, we assessed LEF1 immunohistochemical staining in a series of 23 cases of MCL, as confirmed by staining for cyclin D1 and/or SOX11. We found expression present in one additional case, and evaluated some published literature suggesting a frequency of 4–9% expression of LEF1 by MCL. LEF1 expression by immunohistochemistry in MCL is unusual but can be seen rarely, and could represent a potential diagnostic pitfall.
•LEF1 is expressed in up to 5-10% of mantle cell lymphoma•This may be a potential pitfall in the differential diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and mantle cell lymphoma.•LEF1 is expressed in most cases of CLL/SLL and in normal T cells.
Details
- Title: Subtitle
- Expression of LEF1 in mantle cell lymphoma
- Creators
- Dennis P O'Malley - Neogenomics, Aliso Viejo, CA, United StatesJohn P Lee - University of Iowa Hospitals and Clinics, United StatesAndrew M Bellizzi - University of Iowa Hospitals and Clinics, United States
- Resource Type
- Journal article
- Publication Details
- Annals of diagnostic pathology, Vol.26, pp.57-59
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.anndiagpath.2016.09.016
- PMID
- 28038713
- ISSN
- 1092-9134
- eISSN
- 1532-8198
- Language
- English
- Date published
- 02/2017
- Academic Unit
- Pathology
- Record Identifier
- 9984047689402771
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