Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy

Panagiotis J. Vlachostergios; Foteini Karasavvidou; Grigorios Kakkas; George Moutzouris; Anna Patrikidou; Ioannis A. Voutsadakis; Danai D. Daliani; Elias Zintzaras; Michael D. Melekos; Christos N. Papandreou

doi:10.1155/2012/452795

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Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy

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Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy

Panagiotis J. Vlachostergios, Foteini Karasavvidou, Grigorios Kakkas, George Moutzouris, Anna Patrikidou, Ioannis A. Voutsadakis, Danai D. Daliani, Elias Zintzaras, Michael D. Melekos and Christos N. Papandreou

Prostate cancer, Vol.2012(2012), pp.101-108

01/01/2012

DOI: 10.1155/2012/452795

PMCID: PMC3362215

PMID: 22666602

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Abstract

Objective . To study the impact of the neutral endopeptidase (NEP)/neuropeptides (NPs) axis and nuclear factor kappa B (NF κ B) as predictors of prostate-specific antigen (PSA) recurrence after radical prostatectomy (RP). Patients and Methods . 70 patients with early-stage PC were treated with RP and their tumor samples were evaluated for expression of NEP, endothelin-1 (ET-1) and NF κ B (p65). Time to PSA recurrence was correlated with the examined parameters and combined with preoperative PSA level, Gleason score, pathological TNM (pT) stage, and surgical margin (SM) assessment. Results and Limitations . Membranous expression of NEP ( P < 0.001), cytoplasmic ET-1 ( P = 0.002), and cytoplasmic NF κ B ( P < 0.001) were correlated with time to PSA relapse. NEP was associated with ET-1 ( P < 0.001) and NF κ B ( P < 0.001). ET-1 was also correlated with NF κ B ( P < 0.001). NEP expression ( P = 0.017), pT stage ( P = 0.013), and SMs ( P = 0.036) were independent predictors of time to PSA recurrence. Conclusions . There seems to be a clinical model of NEP/NPs and NF κ B pathways interconnection, with their constituents following inverse patterns of expression in accordance with their biological roles and molecular interrelations.

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Title: Subtitle: Expression of Neutral Endopeptidase, Endothelin-1, and Nuclear Factor Kappa B in Prostate Cancer: Interrelations and Associations with Prostate-Specific Antigen Recurrence after Radical Prostatectomy
Creators: Panagiotis J. Vlachostergios
Foteini Karasavvidou
Grigorios Kakkas
George Moutzouris
Anna Patrikidou
Ioannis A. Voutsadakis
Danai D. Daliani
Elias Zintzaras
Michael D. Melekos
Christos N. Papandreou
Resource Type: Journal article
Publication Details: Prostate cancer, Vol.2012(2012), pp.101-108
DOI: 10.1155/2012/452795
PMID: 22666602
PMCID: PMC3362215
NLM abbreviation: Prostate Cancer
ISSN: 2090-3111
eISSN: 2090-312X
Publisher: Hindawi Publishing Corporation
Language: English
Date published: 01/01/2012
Academic Unit: Internal Medicine
Record Identifier: 9984808211202771

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