Journal article
Expression of P0 protein mRNA along rat sciatic nerve during development
Brain research. Developmental brain research, Vol.83(2), pp.285-288
1994
DOI: 10.1016/0165-3806(94)00149-9
PMID: 7535206
Abstract
The temporal and spatial expression of P0 protein mRNA in the spinal nerve roots and in distal (popliteal trifurcation) segments of the developing rat sciatic nerve was examined using in situ hybridization. P0 mRNA was undetectable in the PNS portions at day 16 post-fertilization (E16) but present in the roots as well as in the sciatic nerve by E18. While Schwann cells were labelled by in situ hybridization at E18, it was not until birth (P1) that cells revealed the typical clusters of silver grains in a perinuclear distribution. Hybridization signal rose between P5 and P10, than decreased at P40, with no significant difference of P0 mRNA levels between the different PNS portions at each age studied. These findings demonstrate the lack of proximo-distal gradient in abundance of P0 mRNA during rat PNS development and add further insight in understanding the dynamics of axonal regulation of myelination in the PNS.
Details
- Title: Subtitle
- Expression of P0 protein mRNA along rat sciatic nerve during development
- Creators
- Pierluigi Baron - Neurology Research, Children's Hospital of Philadelphia, and the Department of Neurology, University of Pennsylvania, Philadelphia, PA, USAMichael Shy - Department of Neurology, Thomas Jefferson School of Medicine, Philadelphia, PA, USAJohn Kamholz - Neurology Research, Children's Hospital of Philadelphia, and the Department of Neurology, University of Pennsylvania, Philadelphia, PA, USAGuglielmo Scarlato - Neurology Research, Children's Hospital of Philadelphia, and the Department of Neurology, University of Pennsylvania, Philadelphia, PA, USADavid Pleasure - Neurology Research, Children's Hospital of Philadelphia, and the Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
- Resource Type
- Journal article
- Publication Details
- Brain research. Developmental brain research, Vol.83(2), pp.285-288
- Publisher
- Elsevier B.V
- DOI
- 10.1016/0165-3806(94)00149-9
- PMID
- 7535206
- ISSN
- 0165-3806
- Language
- English
- Date published
- 1994
- Academic Unit
- Neurology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984020772202771
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