Journal article
Expression of Stem Cell Markers, CD133 and CD44, in Pediatric Solid Tumors: A Study Using Tissue Microarray
Fetal and pediatric pathology, Vol.32(3), pp.192-204
06/01/2013
DOI: 10.3109/15513815.2012.701266
PMID: 22830353
Abstract
Based on the cancer stem cell (CSC) concept model, a small population of cells with unique self-renewal properties and malignant potential exists in tumors. Immunohistochemistry was performed to detect the expression of CSC markers, CD133 and CD44, in a series of pediatric tumors. The association between expression of these markers and tumor characteristics was then analyzed. In Wilms tumors (WT), a significant positive correlation was found between expression of CD133 and the National Wilms Tumor Stage (NWTS) (p = 0.047). In neuroblastomas (NB), expression of CD133 was positively correlated with the International Neuroblastoma Staging System (INSS) (p-value = 0.012), indicating that the rate of CD133 positivity increased with the stage of these tumors. CD133, as a putative stem cell marker, is associated with more advanced stages of Wilms and NB tumors; therefore, this molecule can be a potential clinical prognostic marker in children suffering from NB or Wilms tumor.
Details
- Title: Subtitle
- Expression of Stem Cell Markers, CD133 and CD44, in Pediatric Solid Tumors: A Study Using Tissue Microarray
- Creators
- Mitra Mehrazma - Tehran University of Medical SciencesZahra Madjd - Department of Pathology, Tehran University of Medical Sciences, Tehran, IranElham Kalantari - Tehran University of Medical SciencesMahshid Panahi - Tehran University of Medical SciencesAlireza Hendi - Tehran University of Medical SciencesAhmad Shariftabrizi - Tehran University of Medical Sciences
- Resource Type
- Journal article
- Publication Details
- Fetal and pediatric pathology, Vol.32(3), pp.192-204
- Publisher
- Informa Healthcare
- DOI
- 10.3109/15513815.2012.701266
- PMID
- 22830353
- ISSN
- 1551-3815
- eISSN
- 1551-3823
- Language
- English
- Date published
- 06/01/2013
- Academic Unit
- Radiology
- Record Identifier
- 9984318693302771
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